Objective: To assess if metabolic risk factors are associated with cognitive dysfunction in PD patients.

Background: Metabolic syndrome is known as a risk factor of many neurodegenerative diseases, especially cognitive disorders. However, there was limited literature studying its relationship with PD.

Methods: Study design: Retrospective study conducted between 2014 and 2016  in Queen Elizabeth Hospital, Hong Kong.

The metabolic risk factors were assessed by blood pressure and blood tests (Hba1c, fasting glucose and lipid profile).

1. Hba1c > 6.5%

2. Fasting glucose > 5.6 mmol / L

3. Raised blood pressure ≥ 140 / 90 mmHg; Use of anti-hypertensives

4. Raised serum triglyceride ≥ 1.7 mmol / L

5. Reduced HDL-C < 1.0 mmol / L

The cognitive function was evaluated by Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).

SPSS version 20 was used for statistical analysis.

Chi square and t tests were used to test for differences.

Results: 347 patients were recruited into the study.

A high systolic blood pressure of ≥ 140mmHg was found to be associated with a lower MMSE (P = 0.000) and MoCA score (P = 0.001) (Table 1).

A low serum HDL-C level was shown to be associated with a lower MMSE score (Table 1).

A high systolic blood pressure was reported to be associated with poor performance in a. Orientation b. Attention c. Visuospatial and executive function d. Language e. Abstraction (Table 2).

Conclusions: This study reported that a high systolic blood pressure is associated with cognitive impairment in Parkinson’s disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/high-systolic-blood-pressure-is-associated-with-cognitive-impairment-in-parkinsons-disease-pd/