Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: (i)To elucidate the metabolic correlates sub-serving the clinical expression of ICD in PD and (ii) to evaluate the association between the glucose metabolism and the ICD scores.
Background: A substantial subset of Parkinson’s disease (PD) patients suffers from impulse control disorders (ICD)1. Previous metabolic/ functional neuroimaging studies exhibit a differential activation of reward-related cerebral areas but their methodological heterogeneity makes it difficult to provide firm conclusions2.
Methods: Twenty-two PD-ICD patients according to the QUIP-RS scale, and nineteen healthy controls (HC) underwent [18F]-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in “on drug” state in resting condition. Regional glucose metabolism and its correlations with the QUIP-RS score were assessed using SPM8.
Results: As PD-ICD patients [19 male, 3 female; 59.9±8.7 years old; 8.5±4.2 years of disease evolution; UPDRS ON motor score 19.2±2.29; Daily LEDTOTAL 1446 mg ±129.87] differed from healthy controls (10 male, 9 female; 68. ±3.2 years old) in age and sex, we included them as covariates for comparisons. PD-ICD patients exhibited lower FDG uptake bilaterally in the orbitofrontal cortex (OFC), and to a lesser extent in the left perirhinal cortex than HC without any region of hypermetabolism. QUIP-RS score correlated negatively with FDG uptake in the medial OFC.
Conclusions:
There is a bilateral and non-task related hypometabolism in stimulus-reward association areas in PD-ICD patients compared to HC, which is negatively correlated with the severity of this behavioral disorder.
*This abstract has not been previously published. It has been sent to the “13th International Conference on Alzheimer´s & Parkinson´s Disease” which will take place from March 29 to April 2, 2017 in Vienna, Austria.
References: 1. Weintraub D, Koester J, Potenza MN, et al. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 2010; 67:589-95 2. Voon V, Pessiglione M, Brezing C, et al. Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors. Neuron. 2010 14;65:135-42
To cite this abstract in AMA style:
I. Navalpotro-Gomez, A. Botas-Peñín, F. Molinet-Dronda, C. Gasca-Salas, M. Carmona-Abellán, H. Jiménez-Urbieta, M. Delgado-Alvarado, A. Quiroga-Varela, B. Gago, M.C. Rodríguez-Oroz. Hypometabolism in Orbitofrontal and Perirhinal Cortex is Associated with Impulse Control Disorder in Parkinson´s Disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/hypometabolism-in-orbitofrontal-and-perirhinal-cortex-is-associated-with-impulse-control-disorder-in-parkinsons-disease/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/hypometabolism-in-orbitofrontal-and-perirhinal-cortex-is-associated-with-impulse-control-disorder-in-parkinsons-disease/