Objective: To investigate the neuroimaging marker for dementia in Parkinson’s disease (PD) patients using [18F]FDG PET.

Background: Dementia may occur in patients with PD during the course of disorder. We investigated the neuroimaging marker for dementia in PD patients using [18F]FDG PET.

Methods: We performed [18F]FDG PET for three groups: PD with dementia (n= 23, age: 77.6±6.5), PD without dementia (n= 12, age: 71.8±8.0) and healthy control (n= 16, age: 67.1±7.1) groups. Regional glucose uptake, which was expressed as % of glucose uptake of the whole brain, was obtained in the following cortical regions: dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), posterior parietal cortex (PPC), visual association cortex (VAC), and hippocampus-posterior cortex (H-PCC).

Results: Glucose uptake in the DLPFC was 96.3±5.8 (mean±SD) in the PD-D, 99.5±3.5 in the PD-ND, 100.2±3.1 in the healthy control group (p=0.012, healthy control vs PD-D). Glucose uptake in the OFC was 102.3±4.9 in the PD-D, 98.5±3.5 in the PD-ND, 99.9±3.5 in the healthy control group (p=0.016, PD-D vs PD-ND). Glucose uptake in the PPC was 86.5±3.6 in the PD-D, 99.1±2.9 in the PD-ND, 101.4±2.8 in the healthy control group (p<0.001, PD-D vs PD-ND). Glucose uptake in the VAC was 99.2±6.9 in the PD-D, 100.5±3.2 in the PD-ND, 99.1±2.8 in the healthy control group. Glucose uptake in the H-PCC was 102.6±11.4 in the PD-D, 99.3±4.6 in the PD-ND, 100.4±5.1 in the healthy control group.

Conclusions: Our data showed that the PD-D group was distinguished from the PD-ND group by highly significant reduction of glucose metabolism in the posterior parietal cortex. These observations are consistent with clinical observations that the earliest sign of dementia in PD patients is the impaired visuospatial construction ability.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/hypometabolism-of-the-posterior-parietal-cortex-in-pd-with-dementia-18ffdg-pet-study/