Objective: To determine the impact of vitamins supplements on non-motor fluctuations in people living with Parkinson’s disease (PEP).

Background: Parkinson’s disease (PD) is a neurodegenerative disease with systemic motor and non-motor involvement that reduces the quality of life(1). Non-motor symptoms are of the utmost importance since they can fluctuate similarly to motor symptoms(2). Vitamins are organic substances, necessary for man, some vitamins are not synthesized by the body, and if they do, the amounts are insufficient; then, its external contribution is necessary(3). The non-motor fluctuations assessment (NoMoFA) is a tool that facilitates the identification and quantification of the severity of both static and fluctuating non-motor symptoms (MFN) that occur in (PD)(4).

Method: An observational, retrospective, cross-sectional, and analytical study was carried out. 100 FEP (54.0% men, 61.54 ± 13.2 years) who underwent an evaluation (NoMoFA) and a brief questionnaire on vitamin intake were included as complementary strategies for the treatment of (PD). Data such as weight, height, and BMI were collected. Independent samples t-test was used to compare the means of MDS-UPDRS, No MoFA, PDQ-39, MoCA, and QUICK, and the Mann-Whitney U test was used to compare people who took supplements with those who did not.

Results: The means of weight and height were 67.51±12.3 and 1.60±5 cm, respectively, concentrating a mean of 25.19±1.9 in BMI, to which only (39%) (PEP) reported the intake of some type of vitamins. The means of MDS-UPDRS, No MoFA, PDQ-39, MoCA, and QUICK, consuming vitamins were 58.3 ± 29.3, 10.3 ± 9.48, 35.1 ± 19.9, 19.7 ± 6.04 and 10.8 ± 3.08 respectively.

Using the Mann-Whitney t and U test between those PEP that uses vitamins and those that do not, a significant difference was found in the mean of No MoFA (10.3±9.48 vs. 4.38±5.75; p=0.001) and in the mean range of weight (63.8 vs. 69.8; ( p=0.019), without significant difference in MDS-UPDRS, PDQ-39 MoCA and QUICK.

Conclusion: The intake of vitamins was associated with lower weight and a higher score in No MoFA according to the evaluation of non-motor fluctuations (NoMoFA), however, it is necessary to complement with more studies to conclude its association with clinical worsening in people with (PD) and thus be able to make a specific recommendation on the use or not of vitamins.

References: 1.- Simon E, Aguilera O, Nuñez L, Non-motor symptoms in patients with Parkinson ‘s disease. MEDISAN 2017;21(6):681
2.- Just a moment. . . (s. f.). https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.28507
3.- Ríos, P. M. (2004, 1 septiembre). Vitaminas y salud | Offarm. https://www.elsevier.es/es-revista-offarm-4-articulo-vitaminas-salud-13065403
4.-The Non-Motor Fluctuation Assessment (NoMoFA) Questionnaire. (s. f.). https://www.movementdisorders.org/MDS/MDS-Rating-Scales/NoMoFA.htm

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MDS Abstracts - https://www.mdsabstracts.org/abstract/impact-of-vitamin-supplements-intake-on-non-motor-fluctuations-measured-by-nomofa-in-people-living-with-parkinsons-disease/