Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To investigate the disrupted topographic organization in a cohort of cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease (PDAR), and its potential relationships with the disease severity and the cognitive function in PDAR.
Background: Resting-state functional magnetic resonance imaging (fMRI) and graph theory approaches have been combined to investigate the topographic organization in PD.
Methods: Twenty cognitively unimpaired drug-naïve patients with PDAR and 20 age-, sex-, and education-matched healthy controls were included. Small-world profile and topographic properties (clustering coefficient (Cp), characteristic path length (Lp), local efficiency (Eloc), global efficiency (Eglob), nodal efficiency (Enod), nodal degree (NDeg), and nodal betweenness (NBet)) were measured and compared between two groups, with age, gender and education as covariates. Correlation analyses between topographic features and the unified PD rating scale part-III (UPDRS-III) scores, cognitive scores were performed.
Results: PDAR patients presented the small-world property, and abnormalities at the nodal level (Enod, NDeg, and NBet) but not at the global level (Cp, Lp, Eloc, and Eglob). Our results revealed lower nodal centralities mainly in the occipital lobe and areas of the limbic system (including amygdala nucleus), and higher nodal centralities in distributed regions of frontal, temporal, and parietal lobes (including bilateral posterior cingulate cortex (PCC)). Further, the decreased nodal centralities of the calcarine area and regions of the occipital lobe were negatively correlated with UPDRS-III scores and (or) positively correlated with visuospatial scores, and the increased nodal degree of the PCC was positively correlated with UPDRS-III scores and negatively correlated with memory scores.
Conclusions: The topographic organization was impaired, and the topographic disruption of the calcarine area and the PCC may have a role in disease progression and development of cognitive decline in PDAR patients.
To cite this abstract in AMA style:
Y.B. Hou, Q.Q. Wei, R.W. Ou, J. Yang, W. Song, Q.Y. Gong, H.F. Shang. Impaired topographic organization in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/impaired-topographic-organization-in-cognitively-unimpaired-drug-naive-patients-with-rigidity-dominant-parkinsons-disease/. Accessed June 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/impaired-topographic-organization-in-cognitively-unimpaired-drug-naive-patients-with-rigidity-dominant-parkinsons-disease/