Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To assess the usage frequency of dopamine agonists (DA), the prevalence of impulse control disorder (ICD) in patients with Early-onset Parkinson’s Disease (EOPD), and to explore the potential factors associated with the development of ICD.
Background: Impulse control disorders are characterized by excessive and repetitive behaviors generally affecting patients exposed to DA. In previous studies, it has been reported that 1) there is an increased prevalence of ICD in patients with Parkinson’s disease and 2) ICD occurrence is associated with male sex and earlier disease onset. Patients with EOPD have an earlier disease onset and often face unique clinical and societal challenges. Given these factors and the scant current literature on ICD in EOPD, it is important to improve our understanding of ICD in this vulnerable population.
Method: We used the Mayo Data Explorer system to investigate a population-based cohort of EOPD patients between 1990 and 2022 at Mayo Clinic. We included patients with Parkinson’s disease at or before the age of 50 (according to the current Movement Disorder Society recommendations) diagnosed with ICD. All medical records were reviewed to confirm diagnosis.
Results: A total of 831 (513 males and 318 females) patients with EOPD were included with a mean age at symptom onset of 42 years. DA was used in 49.7% of all patients. 14.5% of the patients using DA had ICD, and among patients using DA, 13% females and 15.4% males had ICD. There was no statistically significant difference in the frequency of ICD between males and females.
Conclusion: Our study demonstrates that DA was frequently used in patients with EOPD and that about 15% of these patients are affected by ICD. Our study also showed that there was no significant difference in the prevalence of ICD development between female and male patients.
Presented on April 24th 2023 at the 75th American Academy of Neurology Annual Meeting in Boston, MA
To cite this abstract in AMA style:
J. Jacobson, K. Ghoniem, A. Mullan, P. Turcano, C. Stang, E. Camerucci, C. Piat, J. Bower, R. Savica. Impulse Control Disorder and medication management in Patients with Early-Onset Parkinson’s Disease [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/impulse-control-disorder-and-medication-management-in-patients-with-early-onset-parkinsons-disease/. Accessed June 14, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/impulse-control-disorder-and-medication-management-in-patients-with-early-onset-parkinsons-disease/