Objective: To investigate the relationships between depression/anxiety and activity limitations in Parkinson disease (PD).

Background: Depression, anxiety are common non-motor symptoms in PD. Depression which the main factor affecting quality of life in PD might lead to physical inactivity. However, there is limited knowledge on the effect of depression/anxiety on physical activity (PA) in PD.

Methods: Identifying the motor functions, clinic disabilities of forty-two volunteers PD were used Hoehn&Yahr (H&Y), the Unified Parkinson’s Disease Rating Scale (UPDRS II, III). Anxiety and depression were measured with Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI). PA parameters were evaluated with SenseWear Armband (SWA) accelerometer for 7 consecutive days. SWA outcome measures were total energy expenditure (TEE, joule), active energy expenditure (AEE, 3 METs-joule), PA duration (3 METs-min). Functional independency in daily living and fatigue was respectively assessed with Schwab&England Activities of Daily Living (S&E ADL), Fatigue Impact Scale (FIS). Spearman’s rank correlation test was used to evaluate correlations between parameters.

Results: There were 17 female, 25 male PD with a median age of 65.50. The median of H&Y, UPDRS II, III were respectively 2.00 (2.00-2.50), 7.00 (4.00-11.00), 23.00 (15.75-29.25). There was a negative correlation between BAI and TEE (moderate; rho=-0.571, p<0.001), AEE (moderate; rho=-0.410, p=0.008), PA duration (weak, rho=-0.327, p=0.037), S&E ADL (moderate; rho=-0.468, p=0.002). There was a negative correlation between BDI and TEE (moderate; rho=-0.504, p=0.001), S&E ADL (moderate; rho=-0.442, p=0.003). There was a positive correlation between UPDRS II and BAI (moderate; rho=0.457, p=0.003), BDI (weak; rho=0.373, p=0.015). There was no significant correlation between UPDRS III and BAI, BDI (p>0.05). A positive correlation was observed between FIS and BAI (weak; rho=0.354, p=0.023), BDI (moderate; rho=0.518, p<0.001).

Conclusions: Anxiety, depression have deteriorative effects on the PA, functional dependency, fatigue, motor capacity of ADL. We suggested that therapeutic approaches should be applied to both anxiety and depression which lead to functional dependence in daily living while PD physiotherapy are primarily based on motor ability. Physical inactivity should be dealed with a multidisciplinary point of view.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/is-there-a-relationship-between-depression-anxiety-and-physical-inactivity-in-parkinson-disease/