Objective: Objective is to demonstrated the role of CYP P450 2D6 polymorphisms in metoclopramide-induced acute dystonic reactions.
Background: Metoclopramide can induce acute extrapyramidal reactions by inhibiting dopamine receptors in basal ganglia.
Method: 10-year-old girl who received metoclopramide developed an acute dystonic reaction. Treatment was immediately discontinued and the side effects resolved. Genotyping was performed by using a PCR-based method.
Results: The patient was homozygous for inactive CYP2D6 gentopyes (CYP2D *4/*4 and CYP2D6 *10/*10), implicating poor drug metabolism.
Conclusion: Metoclopramide-induced acute dystonic reaction may occur in patients carrying a CYP2D6 polymorphisms. Presented case report highlights the importance of genotyping. Pharmacogenetic analysis should be performed when drug toxicity is suspected.
To cite this abstract in AMA style:
I. šarac, H. šarac, F. Borovečki, N. Božina, I. Ivek, L. Bagarić Krakan, Z. Krešić. Metoclopramide-induced acute dystonic reaction caused by CYP2D6 *4/*4 and CYP2D6 *10/*10 genotypes [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/metoclopramide-induced-acute-dystonic-reaction-caused-by-cyp2d6-4-4-and-cyp2d6-10-10-genotypes/. Accessed June 15, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/metoclopramide-induced-acute-dystonic-reaction-caused-by-cyp2d6-4-4-and-cyp2d6-10-10-genotypes/