Session Information
Date: Sunday, October 7, 2018
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: This study aims to characterize the natural history of PSP and to find predictors of shorter survival and early institutionalization including neuroimaging biomarkers.
Background: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. The natural history of PSP has been described in a few studies. Midbrain/pons (M/P) area ratio has been proposed as potential neuroimaging biomarkers for PSP. But no study has explored whether M/P area ratio can predict prognosis of PSP.
Methods: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP. Data were obtained including age, gender, date of onset, age at onset (AAO), initial symptom, side of onset, symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected. Endpoints were death and institutionalization. K-M method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization.
Results: 57 patients fulfilled MDS-PSP criteria were enrolled in our study. 16 patients (28.0%) had died and 26 patients (45.6%) had institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP (HR=0.020, P=0.028), non-PSP-RS phenotype (HR=58.609, P=0.020), early falls (HR=127.765, P=0.012) and decreased M/P area ratio (HR=0.817, P=0.043). Predictors associated with earlier institutionalization were late-onset PSP (HR=0.042, P=0.020) and decreased M/P area ratio (HR=0.913, P=0.035).
Conclusions: Older AAO, non-PSP-RS phenotype, early falls and decreased M/P area ratio were predictors for earlier death while older AAO and decreased M/P area ratio were predictors for earlier institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.
To cite this abstract in AMA style:
S. Cui, S. Chen. Midbrain/pons area ratio and clinical features predict the prognosis of PSP [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/midbrain-pons-area-ratio-and-clinical-features-predict-the-prognosis-of-psp/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/midbrain-pons-area-ratio-and-clinical-features-predict-the-prognosis-of-psp/