Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: We aimed to determine if MPS increases TIA/stroke risk.
Background: Mild Parkinsonian signs (MPS) are a syndrome of mild basal ganglia dysfunction characterized by bradykinesia, rigidity, tremor and gait changes. MPS have been linked to small vessel ischemic disease and the presence of MPS could be a sign of poorly controlled vascular risk factors or an independent risk factor for stroke.
Methods: We prospectively followed a cohort of 1090 patients. Telephone surveys were performed every 6 months assessing for TIA/stroke symptoms over a 2 year period. If symptoms were reported, TIA/stroke was confirmed by chart review. The presence of vascular risk factors (hypertension, hyperlipidemia, diabetes, smoking status and family history of heart disease) was also collected. We described the frequency of baseline MPS and rates of confirmed TIA/stroke, stroke symptoms and prior history of stroke. A logistic regression analysis with stroke symptoms as the dependent variable, MPS as the primary independent variable, and with age, race, gender, and education level as covariates was performed.
Results: We found significant associations between MPS and history of prior stroke (18.3% with MPS vs. 8.8% without MPS; p = 0.001) and between MPS and stroke symptoms over the 2 year follow-up period (23.4% with MPS vs. 15.1% without MPS; p = 0.02). There was also a slightly higher rate of confirmed stroke or TIA over the 2 year follow-up in subjects with MPS, though this was not statistically significant (6.6% with MPS vs. 3.7% without MPS; p = 0.12). Controlling for confounding factors, and stratifying by vascular risk factor did not change the results.
Conclusions: We found that MPS is independently associated with prior TIA/stroke and reported stroke symptoms, though there was not a significant increase in confirmed future TIA/stroke. The underlying pathophysiology between MPS and stroke may be related.
To cite this abstract in AMA style:
J.L. Adams, N. Dahodwala. Mild Parkinsonian signs and TIA/stroke [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/mild-parkinsonian-signs-and-tiastroke/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/mild-parkinsonian-signs-and-tiastroke/