Session Information
Date: Saturday, October 6, 2018
Session Title: Cognitive Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD) and cognitively healthy people.
Background: Motor and non-motor aspects of daily experiences may reflect amyloidogenesis and neurodegeneration in dementia syndromes.
Methods: Consecutive outpatients with probable DLB (fourth consensus report of the DLB Consortium) were paired with outpatients with late-onset AD (National Institute on Aging – Alzheimer’s Association workgroups) by gender, Clinical Dementia Rating (CDR) and Mini-Mental State Examination scores, and with cognitively healthy controls by gender and age (±1 year). Genotyping was undertaken with TaqMan® Real-Time Polymerase Chain Reactions for APOE (rs7412 & rs429358). Cerebrospinal fluid concentrations of amyloid (Aβ42, Aβ40, Aβ38), α-synuclein, and neurofilament light (NFL) were assessed by enzyme-linked immunosorbent assays (ELISA), and correlated with the Schwab and England Scale (S&E), the Movement Disorder Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS parts I/II/III), and the Hoehn and Yahr stages (H&Y).
Results: Overall, 27 participants with DLB (78.48±9.0 years-old, CDR sum-of-boxes 11.00±3.8, eleven APOE-ε4 carriers) were paired with 27 participants with AD (81.00±5.8 years-old, CDR sum-of-boxes 10.46±3.9, twelve APOE-ε4 carriers) and 27 controls (78.48±8.7 years-old, CDR sum-of-boxes 0.41±0.8, four APOE-ε4 carriers). Associations for APOE-ε4 carriers (p<0.001): Aβ42/Aβ40 ratio and Aβ38 associated with S&E in AD; α-synuclein inversely associated with S&E in DLB; NFL inversely associated with S&E in DLB and AD; Aβ38 and α-synuclein inversely associated with MDS-UPDRS-I in DLB, and inversely associated with MDS-UPDRS II & III in AD; NFL associated with MDS-UPDRS II & III in AD. Associations for APOE-ε4 non-carriers (p<0.001): α-synuclein associated with S&E in AD; NFL inversely associated with S&E for all groups; Aβ42/Aβ40 ratio inversely associated with MDS-UPDRS-II for all groups, and inversely associated with H&Y in DLB; Aβ38 and α-synuclein inversely associated with MDS-UPDRS II & III and H&Y in DLB and AD; NFL associated with MDS-UPDRS I & II & III for all groups; NFL associated with H&Y in DLB.
Conclusions: Amyloidogenesis and neurodegeneration differentially affect motor and non-motor features in dementia syndromes.
To cite this abstract in AMA style:
F. Oliveira, M. Miraldo, E. Castro-Neto, F. Machado, S. Almeida, S. Matas, P. Bertolucci, M. Naffah-Mazzacoratti. Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/motor-and-non-motor-correlates-of-apoe-%ce%b54-mediated-cerebrospinal-fluid-concentrations-of-biomarkers-of-amyloidogenesis-and-neurodegeneration-in-dementia-with-lewy-bodies-compared-with-alzheimer/. Accessed May 19, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/motor-and-non-motor-correlates-of-apoe-%ce%b54-mediated-cerebrospinal-fluid-concentrations-of-biomarkers-of-amyloidogenesis-and-neurodegeneration-in-dementia-with-lewy-bodies-compared-with-alzheimer/