Objective: This study aims to evaluate the neuroprotective potential of a natural compound that protects dopaminergic neurons by targeting oxidative stress and cell death pathways in Parkinson’s disease (PD) models.
Background: PD is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss, alpha-synuclein aggregation, and oxidative stress. Emerging evidence has highlighted a critical role of ferroptotic processes and neuroinflammation in PD pathogenesis, and targeting these mechanisms may offer a promising therapeutic strategy to control PD. Natural compound is a natural triterpenoid with potent anti-inflammatory, antioxidant, and anti-apoptotic properties, which may render it a potential neuroprotective agent. This study has explored the therapeutic potential of the natural compound in mitigation of neuroinflammation and neuronal damage using in-vivo and in-vitro models, and thereby provides an advancement in the understanding of its therapeutic potential in PD.
Method: In the present study, rats and SH-SY5Y neurons were exposed to 6-hydroxydopamine (6-OHDA) to induce biomarkers of ferroptosis, apoptosis, neuroinflammation, and PD. Additionally, we also investigated the neuroprotective potential of the natural compound in these in-vivo and in-vitro experimental PD models.
Results: Our findings demonstrated natural compound treatment restored levels of tyrosine hydroxylase and reduced alpha-synuclein accumulation, which were significantly altered in PD. These neuroprotective effects were accompanied by a reduction in oxidative stress, ferroptosis, and apoptosis, which are the key processes implicated in neuroinflammation and neurodegeneration.
Conclusion: These results collectively suggest that alpha-synuclein aggregation, ferroptosis, and apoptotic cell death are critical contributors to PD pathology and highlight natural compound as a promising therapeutic candidate for combating neurodegeneration in PD. These findings open new avenues for developing pharmacological agents targeting the complex mechanisms of PD.
To cite this abstract in AMA style:
S. Pandey, R. Singh. Natural compound Protects Dopaminergic Neurons by Targeting Oxidative Stress and Cell Death Pathways in Parkinson’s Disease [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/natural-compound-protects-dopaminergic-neurons-by-targeting-oxidative-stress-and-cell-death-pathways-in-parkinsons-disease/. Accessed October 5, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/natural-compound-protects-dopaminergic-neurons-by-targeting-oxidative-stress-and-cell-death-pathways-in-parkinsons-disease/