Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor
Objective: To synthesize current experimental and translational evidence supporting the hypothesis that micro- and nanoplastics (MNPs) may contribute to Parkinson’s disease (PD) pathogenesis through neuroinflammatory…SNCA Dysregulation Drives Oxidative Stress and Mitochondrial Dysfunction in Parkinson’s Disease: Evidence from a Punjab Cohort
Objective: This study aimed to investigate SNCA gene alterations alongside oxidative stress and mitochondrial dysfunction in early-onset PD (EOPD) and late-onset PD (LOPD) subjects from the Punjab…Manganese-induced neurotoxicity and Parkinsonian-like syndrome: potential protective role of Opuntia ficus-indica cladode extract in rats
Objective: The objective of this study was to evaluate the antioxidant and neuroprotective effects of an ethanolic extract of Opuntia ficus-indica cladodes against manganese-induced neurotoxicity…Gut Barrier Failure In Parkinson Disease: Reduced Colonic Resilience In Moderate Disease And Spontaneous Pan-Intestinal Leak In Severe Disease
Objective: To determine whether intestinal barrier dysfunction in Parkinson disease (PD) is stage-specific by assessing baseline epithelial permeability and resilience to inflammatory and microbial stressors.…Astrocyte Derived Extracellular Vesicle miR 210 Expression in Exenatide Treated Patients with Parkinson’s Disease
Objective: To investigate miR‑210 expression in astrocyte‑derived extracellular vesicles (ADEVs) from individuals with PD treated with Exenatide versus placebo. Background: Hypoxic stress profoundly alters neuronal…Neuroprotective and Antiparkinsonian Effects of Green-Synthesized Silver Nanoparticles from Eclipta prostrata in a Haloperidol-Induced Murine Model
Objective: To evaluate the antiparkinsonian efficacy of silver nanoparticles synthesized from Eclipta prostrata (SEP) in a haloperidol-induced murine model of Parkinson's disease (PD). Background: Eclipta…Dopamine and Na,K-ATPase: Mechanisms of Direct Enzyme Modulation in the Hippocampus
Objective: This study aimed to investigate the direct effect of dopamine on Na,K-ATPase activity in rat hippocampal membranes and to determine whether this effect depends…Lactobacillus reuteri Y7 Improves Motor and Non-Motor Features Through Gut-Brain-Metabolic Modulation in a 6-OHDA Rat Model of Parkinson’s Disease
Objective: To investigate whether Lactobacillus reuteri Y7 attenuates motor and non-motor impairments in a 6-hydroxydopamine (6-OHDA) rat model of Parkinson’s disease (PD), and to explore potential gut–brain–metabolic…Low-Intensity Treadmill Training Preserves Motor Function and Muscle Mass Through Mitochondrial and Antioxidant Regulation in a Rat Model of Parkinson’s Disease
Objective: To identify an exercise regimen with the greatest neuroprotective benefit in Parkinson’s disease (PD) and determine whether low-intensity treadmill training preserves motor function and…Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum
Objective: To evaluate plasma and PBMC biomarkers of neurodegeneration, neuroinflammation, microglial activation, and oxidative stress across clinically defined stages of Parkinson's disease (PD). Background: PD…
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