The Neuroprotective Effects of Rolipram, a Selective Phosphodiesterase IV Inhibitor, on Parkinson’s Disease in Rat Models: A Pharmacological Exploration in both In vivo and In vitro Settings
Objective: Our research sought to unravel the pharmacological effects and mechanisms of action of Rolipram through both in vivo and in vitro experimentation in models…Role of Telemedicine- Versus Outpatient-Based Initiation And Management of Atkins Diet Therapy In Postmenopausal Women With Drug-Resistant Parkinson’s Disease During The COVID-19 Pandemic
Objective: To explore the satisfaction, effectiveness, and safety of online modified Atkins diet (MAD) initiation and follow-up by comparing a group of work-from-home postmenopausal women…Latent Genetic Architecture of Parkinson’s Disease Risk factors and Comorbidities
Objective: To comprehensively investigate the genetic relationship between Parkinson’s disease (PD), its risk factors, and comorbidities by constructing a factor model of the shared genetic…A pathology-validated study to investigate the role of Uric Acid in Parkinson’s Disease
Objective: The aim of this study is to compare plasma uric acid levels between pathology-confirmed and clinically misdiagnosed Parkinson’s disease patients at a single-patient level.…Impacts of mutations in Parkinson’s disease-related genes on telomere maintenance
Objective: To investigate the correlation between telomere length (TL) and Parkinson’s disease (PD), and whether the change in telomere biology participates in PD pathogenesis. Background:…Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…Identification of potential oxidative biomarkers in saliva of Parkinson’s disease patients
Objective: The goal of this study is to ascertain whether salivary oxidative markers are altered in Parkinson’s Disease (PD) and if there is an association of these markers with disease…Estrogen derivatives and hydrogen peroxide as promising biomarkers in parkinson’s disease-preliminary results
Objective: The study aimed to identify biomarkers of early-stage neurodegeneration in Parkinson’s disease (PD). Background: The currently available diagnostic clinical criteria for PD enable diagnosis…Effects of Eromomastax speciosa in a Gastric Ulcer in a 6-hydroxydopamine (6-OHDA)-induced Rat Model of Parkinson’s Disease.
Objective: To investigate the extract of Eromomastax speciosa neuroprotective/gastroprotective potential in the indomethacin (IND)-induced gastric ulcer in a 6-hydroxydopamine (6-OHDA)-induced PD model. Background: Parkinson's disease…Glycated alpha-synuclein and it emerging role in early onset of Parkinson’s disease
Objective: To elucidate, the molecular mechanism underlying glycated α-Syn mediated dopaminergic (DAergic) neurodegeneration in the substantia nigra (SN) via the AGE/RAGE signaling pathway. Background: Intracytoplasmic…
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