Objective: This study aims to examine the relationship between hippocampal volume, assessed through magnetic resonance imaging (MRI), and MoCA test scores in patients diagnosed with Parkinson’s Disease (PD)
Background: Parkinson’s Disease (PD) is a neurodegenerative disorder that affects mobility and cognitive function. Cognitive decline is prevalent among patients, often linked to hippocampal atrophy.(1) Understanding the correlation between hippocampal volume and cognitive performance can provide valuable biomarkers for early diagnosis and management of cognitive deterioration in PD, ultimately improving patient quality of life. (1)
Method: Forty-eight patients diagnosed with PD were recruited from Parkinson Care and MEX-PD. Informed consent was obtained, and participants underwent the MoCA test alongside MRI to evaluate hippocampal volume. A general linear model was used to analyze the correlation between hippocampal volume and MoCA scores, adjusting for age, sex, and years of education
Results: The findings indicated a significant correlation between left hippocampal volume and hippocampal asymmetry with MoCA scores (p<0.05). Greater left hippocampal volume was associated with better cognitive performance. Furthermore, the asymmetry between hippocampal hemispheres impacted cognition, underscoring the importance of considering these measurements in clinical evaluations.
Conclusion: This study supports the notion that left hippocampal volume and hippocampal asymmetry are significant predictors of cognitive performance in patients with PD. Volumetric measurements may serve as useful biomarkers to enhance the diagnosis and management of cognitive decline in this patient population.
References: Tarhan M, Atalay B, Buz Yaşar A, Özdilek FB. Exploring the cognitive assessment potential of MRI-based volumetric hippocampal segmentation in Parkinson’s disease. Brain Behav. 2024 Jul;14(7):e3576. doi: 10.1002/brb3.3576. PMID: 38970157; PMCID: PMC11226409.
To cite this abstract in AMA style:
Y. Matuk Perez, E. Fernandez Calleja, D. Resendiz Gonzalez, JM. Esquivias Farías, S. Alcauter Solórzano, I. Zamorano-Rangel. Neurodegeneration Biomarkers: Correlation between Hippocampal Volume and Cognitive Performance by MoCA Test in Parkinson’s Disease [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/neurodegeneration-biomarkers-correlation-between-hippocampal-volume-and-cognitive-performance-by-moca-test-in-parkinsons-disease/. Accessed November 20, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/neurodegeneration-biomarkers-correlation-between-hippocampal-volume-and-cognitive-performance-by-moca-test-in-parkinsons-disease/