Correlating Start Hesitation and Subthalamic Nucleus Activity in Parkinson’s Disease Using Intraoperative Microelectrode Recordings and a Virtual Reality Task
Objective: To investigate the modulations in subthalamic nucleus (STN) signals that are associated with prolonged gait initiation duration in a virtual reality gait task in…Early Caudate Dopaminergic Loss as an Imaging Biomarker of Cognitive Impairment in Parkinson’s Disease: A Longitudinal Analysis
Objective: The primary objective was to determine whether early pre-synaptic caudate denervation, measured using 123 I ioflupane SPECT quantitative metrics, provides independent and incremental prognostic value…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Association of Coffee Consumption and Smoking with Cognitive Function in Patients with Early Parkinson’s Disease
Objective: This study investigated cognitive differences among patients with early-stage Parkinson's disease (PD) according to coffee consumption and smoking status. Background: PD is frequently accompanied…Bisphenol S: A Potential Environmental Modifier of LRRK2-Associated Parkinson’s disease
Objective: To validate candidate environmental modifiers in the LIPAD exposomics study using additional cell lines, and test a proposed “gene-mitochondria-environment axis” in regulating LRRK2-Parkinson's disease…DBS withdrawal syndrome in Parkinson’s disease: Clinical features and outcomes of two new cases
Objective: To report two cases of deep brain stimulation (DBS) withdrawal syndrome in Parkinson’s disease (PD), including one without typical risk factors. Background: DBS withdrawal…Clinical, Neuropathological, and Functional Analysis of the Most Prevalent CSF1R Pathogenic Variant, p. Ile794Thr.
Objective: To characterize the clinical presentation, neuropathological findings, and functional consequences associated with the CSF1R p.Ile794Thr variant. Background: CSF1R-related disorder (CSF1R-RD) is a rare, fatal…Sleep Disturbances and Dyskinesia Burden in Parkinson’s Disease: Relevance for Motor Complication Management
Objective: To examine if dyskinesia severity, assessed both clinically and using wearable technology, is independently associated with global and domain-specific sleep disturbance in people with…Strategies for Harmonising Clinical Data for Multi-Centre, Large Scale Genome-Wide Association Studies
Objective: To establish a data harmonisation framework for classifying cognitive status in Parkinson’s disease (PD) across multiple study and data types to facilitate large-scale genetic…Correlational Study of the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD) with Functional Mobility Measures
Objective: To evaluate the correlation between CISI-PD by examining its association with four widely-validated functional mobility measures in PD: the 5 Times Sit-to-Stand Test (5xSTS),…
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