DBS withdrawal syndrome in Parkinson’s disease: Clinical features and outcomes of two new cases
Objective: To report two cases of deep brain stimulation (DBS) withdrawal syndrome in Parkinson’s disease (PD), including one without typical risk factors. Background: DBS withdrawal…The Parkinson’s Impact Project: A Multimodal Longitudinal Study of Disease Development and Progression at the 23andMe Research Institute
Objective: Characterize the interactions between lifestyle, environmental, and genetic exposures on susceptibility to Parkinson’s disease (PD) and progression rates through a scalable remote web-based multimodal…Association of Coffee Consumption and Smoking with Cognitive Function in Patients with Early Parkinson’s Disease
Objective: This study investigated cognitive differences among patients with early-stage Parkinson's disease (PD) according to coffee consumption and smoking status. Background: PD is frequently accompanied…Structural-Functional Decoupling and Imaging Transcriptomics in Cognitive Impairment of Parkinson’s Disease
Objective: To examine SDI across cognitive stages of Parkinson’s disease (PD) and its associations with cortical thickness (CTh), cognition, and cell-type transcriptomic signatures. Background: Cognitive…Distinct Non-Motor Symptom Progression Subtypes in Parkinson’s Disease Identified Using a Data-Driven SuStaIn Model
Objective: To identify progression-oriented non-motor symptom subtypes in PD using a probabilistic Subtype and Stage Inference (SuStaIn) model applied to routinely available clinical assessments. Background:…Voxel-Based Morphometry Reveals Gray Matter Volume Reductions in Sporadic Dystonia
Objective: To investigate gray matter (GM) volume changes in sporadic dystonia (SD) using T1 MRI and voxel-based morphometry (VBM). Background: Dystonia is a hyperkinetic movement…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Effect of subthalamic nucleus deep brain stimulation on heart rate variability in Parkinson’s disease
Objective: To characterize the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on cardiac autonomic regulation at rest and during paced deep breathing in advanced…Skin Tau Quantification as a Potential Degeneration Biomarker in Parkinson’s Disease
Objective: This cross-sectional observational study aims to quantify total skin Tau levels in Parkinson’s disease (PD) patients and explore their association with clinical symptoms. Background:…Altered Motor Regulation and Limbic-Motor Circuits in Paroxysmal Kinesigenic Dyskinesia
Objective: To explore underlying circuit-level mechanisms in paroxysmal kinesigenic dyskinesia (PKD). Background: While the cortico-striato-thalamo-cortical loop and cerebellum are implicated in PKD pathophysiology, the causal…
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