Correlational Study of the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD) with Functional Mobility Measures
Objective: To evaluate the correlation between CISI-PD by examining its association with four widely-validated functional mobility measures in PD: the 5 Times Sit-to-Stand Test (5xSTS),…Benefit of Telemedicine Usage in Parkinson’s Disease Patients in Appalachia
Objective: To assess telehealth patterns on socioeconomic and geographic factors and time to surgery in patients with Parkinson’s Disease (PD) evaluated for deep brain stimulation…Effect of subthalamic nucleus deep brain stimulation on heart rate variability in Parkinson’s disease
Objective: To characterize the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on cardiac autonomic regulation at rest and during paced deep breathing in advanced…Utility of the Short Cognitive and Neuropsychiatric Assessment Scale (ShoCo) in a Multiethnic Asian Cohort of Patients with Progressive Supranuclear Palsy
Objective: To assess the clinical utility of the Short Cognitive and Neuropsychiatric Assessment (ShoCo) scale in a multi-ethnic Malaysian cohort of patients with progressive supranuclear…Cross-Continental Differences in Prodromal Symptoms of Lewy Body Dementia: A Comparative Analysis Across Asia, Europe, and North America
Objective: To systematically analyze the prevalence of prodromal symptoms in Lewy Body Dementia (LBD) across different continents, focusing on REM sleep behavior disorder (RBD), hallucinations,…Altered Motor Regulation and Limbic-Motor Circuits in Paroxysmal Kinesigenic Dyskinesia
Objective: To explore underlying circuit-level mechanisms in paroxysmal kinesigenic dyskinesia (PKD). Background: While the cortico-striato-thalamo-cortical loop and cerebellum are implicated in PKD pathophysiology, the causal…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…A Case of Progressive Cerebellar Syndrome with Ataxia as a First Sign
Objective: To present a case of paraneoplastic cerebellar degeneration whose first sign was ataxia. Background: Paraneoplastic cerebellar degeneration (PCD) is a rare autoimmune syndrome that presents…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Knee Extensor Strength Is Associated with Torque Generation and Mobility in Parkinsonian Disorders
Objective: To examine associations among knee extensor strength (KES), torque generation during knee extension quantified by the area under the torque–time curve (AUC), and functional…
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