Delayed-Onset Rapidly Progressive Parkinsonism After BCMA×CD3 Bispecific Antibody Therapy: A Case Report
Objective: To describe a delayed-onset rapidly progressive parkinsonian syndrome with encephalopathy following BCMA×CD3 bispecific antibody therapy. Background: B-cell maturation antigen (BCMA) × CD3 bispecific antibodies…Predictors of Shunt Placement for Patients with Normal Pressure Hydrocephalus following a Multidisciplinary Evaluation
Objective: Measures of cognition and gait pre- and post-lumbar puncture (LP) may predict which patients with concern for normal pressure hydrocephalus (NPH) are better candidates…An Ongoing Phase 1/2, Multi-center, Open Label Study of NouvNeu001 for the Treatment of Advanced Parkinson’s Disease
Objective: This ongoing, phase 1/2, multi-center, open label study aims to evaluate the safety, tolerability, and efficacy of NouvNeu001 (NCT#06167681) for treating mid to late-stage…Beyond Diagnosis: Putaminal ADC Hyperintensity and Infratentorial Signs Reflect Motor Severity in MSA
Objective: To clarify the clinical significance of neuroimaging markers in multiple system atrophy (MSA) by (1) examining concordance among putaminal MRI markers across sequences, (2)…Modeling the Genetic Complexity of Parkinson’s Disease: Generation of Patient-Specific iPSCs with Co-occurring SNCA/GBA1 and PRKN/LRRK2 Variants
Objective: This study aimed to generate and characterize human induced pluripotent stem cell (iPSC) lines derived from two Parkinson’s Disease (PD) patients carrying combinations of…Does Unilateral MR-Guided Focused Ultrasound Subthalamotomy Provide Bilateral Motor Benefit in Parkinson Disease
Objective: To evaluate the effect of unilateral STN-MRgFUS on ipsilateral motor symptoms at 6 and 12 months post-procedure. Background: In patients with Parkinson’s disease (PD)…Evaluation of Semantic Space Search Metrics in Phonemic Fluency: Comparison among Basal Ganglia Disorders and Healthy Controls
Objective: Phonemic verbal fluency reflects executive function and involves both within-category lexical retrieval (cluster size) and switching between categories. We compared semantic search behavior in…Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…Regional Homogeneity in the Visual Network Mediates between Microbiota and Cognition in Parkinson’s Disease
Objective: We study the role of spontaneous brain activity in the cross-talk between gut microbiota and cognition in PD. Background: Gut dysbiosis is a prevalent…PPP2R5D Variants in Patients Diagnosed With Parkinson’s Disease. A Large‑Scale Multi‑Cohort Analysis
Objective: To identify individuals with rare pathogenic and potentially pathogenic variants of unknown significance (VUS) in PPP2R5D within large Parkinson’s disease (PD) cohorts, to characterize…
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