Behavioral Phenotype of a Mouse Model of Mixed Movement Disorders Linked to ADCY5
Objective: To define the motor and non-motor phenotypic features of a novel Adcy5R419W mouse line [1] and validate it as an integrated model of human mixed movement disorders…Evaluating Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 as Radiographic Metrics to Differentiate Progressive Supranuclear Palsy (PSP) from Normal Pressure Hydrocephalus (NPH)
Objective: We analyze the discriminatory diagnostic value of the Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 in progressive supranuclear palsy (PSP) and normal pressure…Delayed-Onset Rapidly Progressive Parkinsonism After BCMA×CD3 Bispecific Antibody Therapy: A Case Report
Objective: To describe a delayed-onset rapidly progressive parkinsonian syndrome with encephalopathy following BCMA×CD3 bispecific antibody therapy. Background: B-cell maturation antigen (BCMA) × CD3 bispecific antibodies…Beyond Parkinson’s Disease, Impulse Control Dysregulation: The Psychosocial Correlates of Problematic Internet Use
Objective: To determine the prevalence of problematic internet use and associated psychosocial correlates as a phenotype of impulse control dysregulation among undergraduates. Background: Impulse control…Gut Barrier Failure In Parkinson Disease: Reduced Colonic Resilience In Moderate Disease And Spontaneous Pan-Intestinal Leak In Severe Disease
Objective: To determine whether intestinal barrier dysfunction in Parkinson disease (PD) is stage-specific by assessing baseline epithelial permeability and resilience to inflammatory and microbial stressors.…Association between Sleep Behaviors and Age at Onset of Parkinson’s Disease
Objective: To investigate the associations between multiple sleep behaviors and the age at onset (AAO) of Parkinson’s disease (PD) using the UK Biobank. Background: Sleep…Family Caregivers and eHealth in Parkinson’s Disease: Insights From a Qualitative Study
Objective: To explore family caregivers’ views on the role of eHealth in formal care and in supporting physical activity and exercise for people with Parkinson’s…Motor and Quality‑of‑Life Outcomes After MR‑Guided Focused Ultrasound Subthalamotomy for Parkinson’s Disease: A Meta‑analysis
Objective: To evaluate the efficacy and safety of MR guided focused ultrasound (MRgFUS) subthalamotomy for improving motor symptoms, medication burden, and quality of life inParkinson’s…In Vivo 18F-Florzolotau Tau PET Imaging in Parkinson’s Disease with and without Probable REM Sleep Behavior Disorder
Objective: To investigate the distribution and potential influence of tau pathology in Parkinson’s disease (PD) patients with and without prodromal REM sleep behavior disorder (pRBD),…Corticobasal Degeneration With Alien Limb Phenomenon and Severe Cognitive Decline: A Levodopa-Resistant Clinical Case
Objective: To describe a clinical case of corticobasal degeneration presenting with alien limb phenomenon, severe cognitive decline, and resistance to high-dose levodopa therapy. Background: Corticobasal…
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