Demystifying the Delivery of Multi-arm Multi-stage Platform Trials for Parkinson’s Disease –Framework and Recommendations from EJS ACT-PD
Objective: To develop a framework of protocol-aligned rater training, educational resources, and inter-site engagement (Stage 1). The secondary aim was to assess the perceived usefulness…Movement decoding from subthalamic nucleus during deep brain stimulation surgery
Objective: To evaluate motor classification and somatotopy of local field potentials (LFPs) recorded from subthalamic nucleus (STN) directional deep brain stimulation (DBS) electrodes. Background: STN…Beyond Parkinson’s Disease, Impulse Control Dysregulation: The Psychosocial Correlates of Problematic Internet Use
Objective: To determine the prevalence of problematic internet use and associated psychosocial correlates as a phenotype of impulse control dysregulation among undergraduates. Background: Impulse control…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…Risk of Ischemic Cerebrovascular Events in Patients with Deep Brain Stimulation for Parkinson’s Disease: A Cohort Study
Objective: To longitudinally assess the risk of ischemic cerebrovascular events in patients undergoing DBS Background: Longitudinal data on the potential impact of DBS on long-term…Robot-Assisted Transplantation of Hypoimmune iPSC Derived Dopaminergic Progenitor Cells for Idiopathic Parkinson’s Disease
Objective: This study aimed to evaluate the 12-month safety and preliminary efficacy of NCR201 transplantation in idiopathic PD patients, providing a proof-of-concept for universal cell…Clinical Impact of Nicotine in Parkinson’s Disease: Evidence from Randomized Controlled Studies
Objective: To evaluate the effects of nicotine versus placebo in Parkinson’s disease (PD). Background: Nicotine may influence dopaminergic and non‑dopaminergic pathways relevant to PD. While…Transcutaneous Spinal Cord Stimulation in Hereditary Spastic Paraplegias
Objective: To assess transcutaneous spinal cord stimulation (tSCS) as a treatment for hereditary spastic paraplegias (HSPs). Background: Hereditary spastic paraplegias (HSPs) are genetic disorders characterized…An artificial intelligence-based model to predict Parkinson’s disease risk: the AI-PRA study protocol.
Objective: To present the protocol of the Artificial Intelligence-based Parkinson’s Risk Assessment (AI-PRA) study which aims to validate a novel personalised PD risk prediction model…Genetically proven Juvenile-Onset Niemann–Pick Disease Type C Presenting with Dystonia- Ataxia syndrome.
Objective: We present a case Juvenile-Onset Niemann–Pick Disease Type C (NPC) who Presented to us with progressive Dystonia- Ataxia syndrome. Background: Niemann–Pick disease type C…
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