Cerebrovascular reactivity in Parkinson’s disease: acute effects of Levodopa assessed by transcranial doppler
Objective: To evaluate CVR in people with PD (pwPD) and its acute modulation after Levodopa administration. Background: Parkinson’s disease (PD) is associated with neurovascular unit…Skin Biopsy for Phosphorylated Alpha-Synuclein and DAT Imaging in Patients Diagnosed with Psychogenic Parkinsonism
Objective: Objective:Describe the results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) and dopamine transporter (DAT) imaging in patients previously diagnosed with psychogenic parkinsonism (PP) and…Complete Resolution of Troublesome Dyskinesia in People With Advanced Parkinson’s Disease Treated With Foslevodopa/Foscarbidopa: Post Hoc Analysis From a 52-Week Phase 3 Trial
Objective: To evaluate the achievement of complete elimination of troublesome dyskinesia (TSD) and associated changes in Off time, motor aspects of experiences of daily living…Micrographia in Parkinson’s Disease and Multiple System Atrophy: A Quantitative Tablet-Based Handwriting Study
Objective: To evaluate the relative contributions of cognitive and motor factors to handwriting performance in patients with MSA and PD using quantitative tablet-based tasks. Background:…Cerebellar-Basal Ganglia Circuitry in the Pathogenesis of Parkinsonian Postural Instability
Objective: To elucidate the role of impaired interactions between the basal ganglia and the cerebellum in the PI development in PD patients. Background: Postural instability…Urine and Plasma Bis(monoacylglycero)phosphate (BMP) in Asian LRRK2 p.G2385R and p.R1628P Variant Carriers with Parkinson’s Disease
Objective: To compare urine and plasma bis(monoacylglycero)phosphate (BMP) levels in Parkinson disease (PD) patients carrying Asian-prevalent LRRK2 variants (p.G2385R, p.R1628P) against idiopathic PD (iPD) and…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Spatiotemporal Biomarkers of Early Postural Instability in Parkinson’s Disease: Implications for Early Intervention
Objective: To characterize spatiotemporal biomarkers derived from a quantitatively assessed pull test in patients with early Parkinson’s disease (PD). Background: The pull test is a…Local Glymphatic Dysfunction in Multiple System Atrophy: Insights from Multimodal MRI
Objective: To evaluate multimodal glymphatic-related MRI proxies in multiple system atrophy (MSA) and explore their relationship with clinical features. Background: Impaired fluid transport and waste…Disease Burden Profile of Patients with Spinocerebellar Ataxia in China: A Real-World Registry Study (2025)
Objective: To analyze the clinical characteristics, diagnostic pathways, and socioeconomic impact on newly registered SCA patients in China during the year 2025. Background: Spinocerebellar ataxia…
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