Dropped Head Syndrome From Combined MT‑TE and MT‑ND1 Mitochondrial Variants
Objective: To report a case of dropped head syndrome (DHS) associated with both Parkinson's Disease (PD) and biopsy-proven mitochondrial myopathy in a patient carrying coexisting…Changing the ‘Game’: The Impact of ‘Serious Games’-based Cognitive Training on Cognitive Function in Parkinson’s Disease
Objective: We evaluated the impact of NeuroOrb, a novel, accessible “Serious Gaming” computerised cognitive training (CT) platform, on cognitive function, mood and quality of life…Cerebrovascular reactivity in Parkinson’s disease: acute effects of Levodopa assessed by transcranial doppler
Objective: To evaluate CVR in people with PD (pwPD) and its acute modulation after Levodopa administration. Background: Parkinson’s disease (PD) is associated with neurovascular unit…Receptor Selectivity Profile and Clinical Significance of Ecopipam and Its Metabolites as a Potential Therapy for Tourette Syndrome
Objective: To characterize the binding/inhibition and potential clinical relevance of ecopipam and its metabolites across a wide array of potential off-target receptors, ion channels, enzymes,…Skin Biopsy for Phosphorylated Alpha-Synuclein and DAT Imaging in Patients Diagnosed with Psychogenic Parkinsonism
Objective: Objective:Describe the results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) and dopamine transporter (DAT) imaging in patients previously diagnosed with psychogenic parkinsonism (PP) and…Multi-Target Neurobiological Mechanisms of Acupuncture in Levodopa-Induced Dyskinesia: From Dopamine Stabilization to Network Plasticity Modulation
Objective: To elucidate the neurobiological mechanisms through which acupuncture may alleviate levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Levodopa-induced dyskinesia (LID) is a frequent…Effects of Modafinil on Motor and Non‑Motor Outcomes in Parkinson’s Disease: A Meta‑Analysis of Randomized, Placebo‑Controlled Trials
Objective: To determine the efficacy and safety of modafinil on motor and non-motor outcomes in Parkinson’s disease (PD) using evidence exclusively from randomized placebo‑controlled clinical…A Deep Learning Model-based Screening System for Nystagmus in Central Vertigo
Objective: We aimed to classify nystagmus videos into central and peripheral nystagmus using a deep learning model. Background: Diverse causes underlie vertigo, and while clinically…Association Between Sleep Disturbance and Fatigue in Patients with Parkinson’s Disease
Objective: This study aimed to comprehensively investigate the associations between sleep disturbance and several non-motor symptoms, with a particular focus on the relationship with fatigue.…Performance of the functional staging of Parkinson’s disease using the Neuronal aSynuclein Disease Integrated Staging System (NSD-ISS) in the Critical Path for Parkinson’s (CPP) Integrated Parkinson’s Database
Objective: To evaluate the utility of the NSD-ISS for clinical staging of Parkinson’s disease (PD) by examining stage distribution, longitudinal stage transitions, and demographic predictors…
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