Intrinsic Suppression of the NRF2–Ferroptosis Defense Axis Defines Selective Vulnerability of D2-Striosome Neurons in Huntington’s Disease
Objective: This study mapped baseline stress-response and cell death programs in healthy human striatal populations to identify intrinsic molecular constraints in D2-striosome neurons and their…Childhood-Onset Spastic Paraparesis Followed by Early-Onset Parkinsonism: A Genetically Unresolved Case of Complicated Hereditary Spastic Paraplegia
Objective: to present a rare case of patient with childhood-onset spastic paraparesis who developed early-onset Parkinson's disease. Background: Approximately 21% of HSP patients develop parkinsonism,…Changing the ‘Game’: The Impact of ‘Serious Games’-based Cognitive Training on Cognitive Function in Parkinson’s Disease
Objective: We evaluated the impact of NeuroOrb, a novel, accessible “Serious Gaming” computerised cognitive training (CT) platform, on cognitive function, mood and quality of life…Exploring the Relationship Between Circadian Disruption, Depression and Suicidal Ideation in People with Huntington’s Disease (Mind & Clock Study)
Objective: To examine the relationship between circadian and sleep disruptions and depressive symptoms and suicidal ideation in people with Huntington’s Disease (PwHD) using scale-based and…Predictors of Clinical Progression Over a Decade in GBA1 versus LRRK2 Non-Manifesting Carriers
Objective: To determine whether presence of synucleinopathy and dopaminergic biomarkers, either alone or in combination, predict phenoconversion to Parkinson’s disease (PD) differentially in GBA versus…Spatiotemporal Trajectories of Plasma Biomarkers and Diffusion MRI Metrics in Parkinson’s Disease
Objective: To investigate the spatiotemporal dynamics of multimodal biomarkers and their role in early prediction of cognitive decline. Background: Cognitive impairment is a major source…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…A Methodological Framework for Selecting Digital Gait Outcomes in Clinical Trials
Objective: To present a systematic framework for identifying the most sensitive, reliable, and valid digital gait measures to be used as digital endpoint in clinical…Multi-Target Neurobiological Mechanisms of Acupuncture in Levodopa-Induced Dyskinesia: From Dopamine Stabilization to Network Plasticity Modulation
Objective: To elucidate the neurobiological mechanisms through which acupuncture may alleviate levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Levodopa-induced dyskinesia (LID) is a frequent…Strengthening Global Parkinson’s Disease Research Capacity through the GP2 ‘Train the Trainer’ Framework
Objective: To implement a sustainable ‘Train the Trainer’ model to strengthen research capacity in Parkinson’s disease (PD) genetics across underrepresented regions (URPs). This initiative promotes…
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