Clinical effects are persistent at the end of one abobotulinumtoxinA injection cycle in cervical dystonia – results from a meta-analysis of 1091 subjects
Objective: Evaluate the impact of one injection cycle of abobotulinumtoxinA (AboBoNT-A; Dysport®) on the clinical characteristics of cervical dystonia (CD). Background: The pharmacologic effects of…Brainstem connection of Writer’s cramp: Electrophysiological correlates
Objective: In this study, we explored the involvement of brainstem in Writer’s cramp (WC) patients through pre-pulse inhibition of blink reflex and Start-React paradigm. Background:…Non motor symptoms in patients with Writer’s cramp
Objective: We aim to explore the non-motor features of WC patients and correlate those with motor symptoms. Background: Writer’s cramp (WC) is essentially a motor…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.Development of a New Kinematic Model for Head and Neck Movement Assessment in Cervical Dystonia
Objective: The aim of this study is the development of a new kinematic model for cervical spine to assess abnormal head and neck postures and…Dystonia-like phenotype in a DYT1 rat model after peripheral trauma
Objective: Establishment and characterization of a DYT1 rat model with dystonia-like movements after sciatic nerve crush injury. Background: Penetrance of DYT1 dystonia is markedly reduced…Assessing the involvement of ARSG and RAB12 variants in Musician’s Focal Dystonia from the US.
Objective: To assess the involvement of genetic risk factors in implicated genes in a US cohort with musician's focal dystonia (MFD). Background: MFD affects 1-2%…Striatal Cholinergic Neurons in Cervical Dystonia
Objective: To determine if there is cholinergic neuronal loss in the putamen in cervical dystonia. Background: The etiology of cervical dystonia is unknown. Striatal cholinergic…Research on Relationship between Sensory Tricks of Cervical Dystonia and Function of Cerebral Cortex
Objective: To investigate demography of sensory tricks in cervical dystonia, to discuss relationship between sensory tricks and function of sensorimotor integration in supplementary motor area of…A kinematic analysis of finger tapping in dystonia
Objective: To perform a computerised analysis of finger tapping in patients with dystonia and healthy controls in order to develop a better understanding of the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.