Circadian modifications in Parkinson disease
Objective: To observe the expression of circadian rhythm related genes Bmal1 and melatonin receptors in different brain regions of 6-OHDA-induced acute Parkinson's disease rats. Background:…Sexual Dysfunction in Women with Parkinson’s Disease
Objective: To assess the prevalence and severity of sexual dysfunction (SD) in women with Parkinson’s Disease (PD) in comparison to general population (GP), highlight the…Efficacy of incobotulinumtoxinA in patients with sialorrhea, as assessed using the modified Radboud Oral Motor Inventory for Parkinson’s disease (mROMP): Results of the SIAXI study
Objective: The pivotal double-blind, randomised Phase III SIAXI study (NCT02091739), assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U for sialorrhea. Co-primary endpoints…The phenomenology of visual hallucinations in Parkinson’s disease: A descriptive analysis of Myanmar and Thai patients
Objective: To describe the phenomenology of visual hallucinations in Myanmar and Thai PD patients. Background: Visual hallucinations are frequently reported by Parkinson’s disease (PD) patients,…Total CSF alpha-synuclein is inversely associated with non-motor symptoms in a population of patients with Parkinson’s Disease
Objective: To evaluate the association between PD non-motor symptoms (NMS) and CSF levels of neurodegeneration-related proteins in a population of PD patients, aimed at identifying…Effect of CDNF on non-motor symptoms like motivation, fear, stress and depression-like behavior
Objective: The goal of this study was to characterize the effect of CDNF on motivation, stress and depression-like behavior, because most of the non-motor symptoms,…Non-Motor Symptom In Young Onset Parkinson Disease as a Cause of Pharmacoresistence In Epilepsy
Objective: To report an interesting initial presentation of PD causing refractory epilepsy. Background: A lady with refractory depression, presented with first seizure at age 42,…Predictors and biomarkers of pain in newly diagnosed Parkinson’s disease patients during a two-year follow-up
Objective: To identify clinical characteristics, predictors and biomarkers of pain at baseline and after a two-year follow-up period in newly diagnosed drug-naïve Parkinson's Disease (PD)…The Gut Microbiota in a Canadian Parkinson’s Disease Cohort
Objective: To compare the gut microbiota between PD patients and matched controls in a Canadian cohort and to examine correlations between microbes and disease parameters…Temporal evolution of biomarkers from healthy ageing, isolated REM sleep behavior to early Parkinson’s disease
Objective: To study the temporal evolution of biomarkers of various modalities in healthy ageing controls (HC), the prodromal condition of isolated REM sleep behavior disorder…
