DNAJC13 in Parkinson’s disease; characterization of the p.N855S knock-in mouse model
Objective: To study the effects of DNAJC13 p.Asn855Ser mutant gene dysfunction in a physiological context, and to help define molecular mechanisms for disease, using a…Therapeutic intervention of LRRK2 kinase inhibitors in Vps35 p.D620N Parkinsonism
Objective: To explore the therapeutic potential of LRRK2 kinase inhibitors in a Vps35 p.D620N mouse model of Parkinsonsim. Background: The discovery of a missense mutation, Vps35 p.D620N…Evaluation of nigral neuronal apoptosis during postnatal development and adulthood of mice strains with differential sensitivity to MPTP
Objective: Compare nigral neurons in C57BL/6J, CD-1 and their F1 crossbreds with respect to developmental apoptosis in the nigra during postnatal and to assess MPTP-induced…Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted DAT endocytosis
Objective: In this study, we examine the regulatory role of flotillin-1 in dopamine transporter (DAT) trafficking and the impact of extracellular α-synuclein (αS) on this…RNA binding protein mediated regulation of striatal transcriptome in Parkinson’s disease.
Objective: To investigate the role of RNA binding protein Elavl in Parkinson’s disease related adaptive changes in the striatal transcriptome. Background: Elav-like (Elavl or Hu)…Lymphocyte Senescence in Parkinson’s Disease
Objective: To characterise T- and B-lymphocyte senescence in early stage Parkinson’s disease (PD). Background: Evidence suggests that the immune system may contribute to PD aetiopathogenesis,…Dorsolateral striatal neuronal activity in a rat model of Parkinson`s disease with levodopa-induced dyskinesias
Objective: This study aimed to investigate the firing properties of fast spiking interneurons (FSIs) and medium spiny neurons (MSNs) of the dorsomedial striatum (DLStr) and…Local field potential recordings in the human pallidum using externalized directional DBS leads
Objective: To characterize the spatial distribution and spectral profile of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in…The Level of Neuroendocrine Hormones in Parkinson´s Disease and their Potential Role as Biomarkers : A Pilot Study
Objective: To elucidate the role of neuroendocrine hormones in Parkinson’s disease (PD) and evaluate their potential utilization as biomarkers. Background: A growing body of evidence,…Parkinson’s Disease Correlates with Reduced Risk of Hypertension
Objective: The aim of the present study was to assess the prevalence of hypertension according to the duration of PD.The aim of the present study…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.