MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Local field potential recordings in the human pallidum using externalized directional DBS leads

L. Johnson, J. Aman, D. Escobar Sanabria, J. Wang, R. Patriat, M. Petrucci, M. Hill, G. Molnar, S. Cooper, L. Schrock, C. Mackinnon, N. Harel, M. Park, J. Vitek (Minneapolis, MN, USA)

Meeting: 2019 International Congress

Abstract Number: 1768

Keywords: Deep brain stimulation (DBS), Pallidum, Parkinsonism

Session Information

Date: Wednesday, September 25, 2019

Session Title: Physiology and Pathophysiology

Session Time: 1:15pm-2:45pm

Location: Les Muses, Level 3

Objective: To characterize the spatial distribution and spectral profile of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in patients with Parkinson’s disease (PD) using directional deep brain stimulation (DBS) leads.

Background: Recordings from directional DBS leads may provide a greater understanding of the role of LFP activity in the pathophysiology of PD and in the selection of contact(s) that optimize clinical benefit. This understanding can inform the development of new stimulation approaches and development of programming algorithms that will further improve clinical outcomes for PD patients undergoing pallidal DBS.

Method: Pallidal LFPs were recorded from externalized leads of 3 patients. Pre-operative high resolution 7-T MR images were registered to post-operative CT scans to determine lead location and electrode segment orientation in the GPi. The spatial distribution of oscillatory activity across lead segments was examined in the context of lead locations and clinical DBS settings.

Results: The spatial topography and spectral profile of oscillatory activity in the 5-35Hz range was highly subject-specific. Consistent across patients, however, was the finding that lead segments facing the posterior-lateral “sensorimotor” regions of GPi had the highest oscillatory power, whereas medial (internal capsule) facing segments had the weakest oscillatory power. Similar to what has been observed in recent studies using directional leads in the STN, DBS lead contacts chosen for optimizing clinical benefit, which were blinded to LFP analyses, incorporated lead segments with the strongest LFP activity in the 5-35Hz frequency range.

Conclusion: These findings are supportive of the hypothesis that LFP activity in the 5-35Hz range is greatest in the sensorimotor territory of the GPi and appeared to correlate with the site of stimulation that gave the greatest clinical benefit. These results support further exploration of the relationships between the spatial distribution of LFP activity, patient phenotype, and therapeutic contact selection, and highlight the need for DBS approaches based on subject-specific LFP biomarkers.

To cite this abstract in AMA style:

L. Johnson, J. Aman, D. Escobar Sanabria, J. Wang, R. Patriat, M. Petrucci, M. Hill, G. Molnar, S. Cooper, L. Schrock, C. Mackinnon, N. Harel, M. Park, J. Vitek. Local field potential recordings in the human pallidum using externalized directional DBS leads [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/local-field-potential-recordings-in-the-human-pallidum-using-externalized-directional-dbs-leads/. Accessed July 15, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2019 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/local-field-potential-recordings-in-the-human-pallidum-using-externalized-directional-dbs-leads/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Life expectancy with and without Parkinson’s disease in the general population
  • An atypical and interesting feature of Parkinson´s disease
  • Screening and Treatment of Depression in Parkinson’s Disease within Movement Disorders Centers: A Quality Improvement Initiative
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • #25676 (not found)
  • Crack Dancing: An Uncommon Drug-Induced Chorea
  • #24376 (not found)
  • An atypical and interesting feature of Parkinson´s disease
  • A Case of Pregabalin induced Parkinsonism
  • A survey-based analysis of abnormal movements in patients with Postural Tachycardia Syndrome (PoTS)
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley