Effectiveness aNd use of fosleVOdopa-foscarbidopa in advanced Parkinson disease in real Life setting in France (ENVOL study): interim analysis
Objective: To assess the real-world (RW) effectiveness of continuous subcutaneous infusion of foslevodopa/foscarbidopa (LDp/CDp) over a 12-month follow-up. Background: LDp/CDp is a continuous 24-hour subcutaneous…Rates Of Phenoconvertion And Progression To Functionally Meaningful Impairment In NSD Stage 2B Participants: PPMI cohort
Objective: Describe rates of phenoconversion and progression to functionally meaningful impairment in early Neuronal α-Synuclein Disease (NSD). Background: There is increasing focus on testing disease…AI-based Progression and Medication Response Prediction in Parkinson’s Disease: the AI-PMP Study Protocol
Objective: To evaluate proof-of-concept performance of two artificial intelligence (AI) multivariable models predicting (1) motor disease progression and (2) treatment-related side effects over 12 months…Loss of NAA60-mediated N-terminal acetylation cause primary brain calcification with disturbed Golgi- and phosphate-maintenance functions
Objective: Our ongoing study describes new NAA60-PBC cases, functionally characterizes additional NAA60 protein variants and investigates the cellular mechanisms underlying NAA60-PBC. Background: NAA60 is a…Lysosomal polygenic risk score in Parkinson disease across populations.
Objective: (1) Evaluation of lyso-PRS performance for PD status across diverse populations; (2) Comparison of the lyso-PRS across idiopathic PD (iPD), GBA1-PD, non-manifesting GBA1 carriers…Risk of Serotonin Syndrome in the Combined Use of Selective Monoamine Oxidase B Inhibitors and Serotonin-acting Antidepressants
Objective: We aim to determine the risk of serotonin syndrome with selective monoamine oxidase B inhibitors (MAO-Bi) use, especially when combined with serotonin-acting antidepressants. Background:…All Left: A Case of Ipsilateral Stimulation Induced Dyskinesia
Objective: Stimulation induced dyskinesia is a known phenomenon in subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson’s disease. However, stimulation induced dyskinesia affecting the…When Presynaptic Stimulation is Not Enough: Severe Biphasic Dyskinesia on LECIG Reversed by Postsynaptic Apomorphine Rescue
Objective: To report an exceptional case of advanced Parkinson’s disease (PD) where levodopa/carbidopa/entacapone intestinal gel (LECIG) failed to provide adequate motor control, ultimately requiring a…Nationwide Prevalence of Parkinson’s Disease in Slovakia: A Municipality-Level Analysis
Objective: To determine the nationwide prevalence of Parkinson’s disease (PD) in Slovakia at the level of individual municipalities, with the aim of identifying potential local…DBS withdrawal syndrome in Parkinson’s disease: Clinical features and outcomes of two new cases
Objective: To report two cases of deep brain stimulation (DBS) withdrawal syndrome in Parkinson’s disease (PD), including one without typical risk factors. Background: DBS withdrawal…
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