Clinical characterization of pramipexole induced edema in Parkinson’s disease (PD). Is it always the best option discontinue the treatment?
Objective: Report a patient with PD treated with irregular doses of pramipexole and extensive chronic edema in lower extremities after 8 years of treatment, taking…The unfolded protein response pathway as a possible therapeutic target for the synucleinopathies
Objective: To investigate whether the pharmacological inhibition of unfolded protein response (UPR) pathway would be beneficial in cellular model of synucleinopathies. Background: It has been…May early introduction of dopaminergic agonists improve simptoms after ischemic stroke? The interim report
Objective: To evaluate the effect of bromocriptine on motor impairment, functional disabilit and cognitive impairment 5, 10, and 15 of bromocriptine therapy in patients with…A computational model of iron transport between the blood circulation and the brain
Objective: To create a mechanistic computational model of iron transport between the circulation and brain, permitting in silico investigation of homeostatic regulation of iron at…Long-term effects of levodopa/carbidopa intestinal gel infusion in advanced Parkinson’s disease patients: Dutch multicenter retrospective cohort study
Objective: To determine the long-term outcomes of levodopa/carbidopa intestinal gel infusion (LCIG) in advanced Parkinson's disease (PD) patients. Background: LCIG was introduced in the Netherlands…Inhibition of cathepsin D enhances the autophagy lysosome pathway dysfunction and α-synuclein aggregation in experimental parkinsonism
Objective: To explore the mechanism of CTSD inhibition in the dysfunction of autophagy-lysosome pathway and aggregation of α-synuclein in Parkinson's disease. Background: α-synuclein, the main…Rotigotine transdermal patch in Chinese patients with advanced Parkinson’s disease: A randomized, double-blind study
Objective: A multicenter phase III study (SP1037; NCT01646255) to investigate the efficacy and safety of rotigotine in Chinese patients with advanced Parkinson's disease (PD). Background:…Elemental profiles as biomarkers for diagnosis and disease progression of Parkinson’s disease
Objective: This study aims to analyse the elemental profiles in the cerebrospinal fluid (CSF) of patients with idiopathic Parkinson´s disease (PD) and age-matched control patients…The effect of walking speed on postural stability in Parkinson’s disease fallers
Objective: This cross-sectional study aimed to evaluate the effect of imposed faster and slower walking speeds on gait rhythmicity in people with Parkinson's disease (PD)…Effects of videogame step training on gait adaptability in people with Parkinson´s disease – A randomized controlled trial
Objective: To evaluate the effect of home-based interactive videogame step training on gait adaptability performance in people with Parkinson's disease (PD). Background: The ability to…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.