Multimodal Information Exploration for Automated Clinical Scale Prediction in Neurodegenerative Diseases
Objective: The primary objective of this study was to develop and evaluate machine learning methods for the automatic prediction of standardized clinical scales using multimodal…Racial Disparities in End-of-Life Care among Patients with Advanced Movement Disorders in an Interdisciplinary Supportive Care Clinic
Objective: To examine whether an interdisciplinary supportive care clinic model mitigates racial disparities in advance care planning (ACP), hospice utilization, and place of death among…Integrative Analysis of GBA1 Mutations and GCase Deficiency in Parkinson’s Disease using Long Read Nanopore Sequencing
Objective: To sequence the GBA1 gene in PD patients with reduced GCase activity using nanopore amplicon-targeted sequencing.To characterize benign, VUS, and pathogenic GBA1 variants. Background:…Can a slogan poster featuring the patient’s primary physician help improve gait and prevent falls at home in patients with Parkinson’s disease?
Objective: To present cases with Parkinson’s disease (PD) suggesting that a slogan poster aimed at improving gait and preventing falls may be effective. Background: Patients…Effects of Auricular Vagus Nerve Stimulation Combined with Neurorehabilitation on Motor Symptoms, Balance, and Gait in People with Parkinson’s Disease: Preliminary Results of a Prospective Study
Objective: This study aimed to examine the effects of auricular vagus nerve stimulation (aVNS) combined with neurorehabilitation on motor symptoms, balance, and gait in people…Fracture Burden and Health-Related Quality of Life in Older Adults with Parkinson’s Disease in Rural India: A Community-Based Study
Objective: This study aimed to examine the relationship between fracture history and health-related quality of life (HRQoL) among elderly individuals with Parkinson’s disease residing in…Patient perspectives on meaningful symptoms and disease progression in Parkinson’s Disease (PD): Interim findings from the Patient Endpoint Preference Project (PEPP)
Objective: The Patient Endpoint Preference Project (PEPP) aims to identify and quantify early‑stage PD patients’ priorities around symptoms and their progression using patient‑reported questionnaires. The…Translational evaluation of CSF as a relevant compartment for assessing target engagement of therapeutic anti–α-syn antibodies.
Objective: To evaluate a translational free/total α-synuclein (α-syn) assay framework to quantify in vivo target engagement (TE) of anti–α-syn antibodies in preclinical models and to…Subtype-specific alterations of iron deposition and neuromelanin loss in the substantia nigra of Parkinson’s disease
Objective: To investigate the specific pathological changes in the substantia nigra (SN) across Parkinson’s disease (PD) subtypes, focusing on iron deposition and NM depletion both…Limited Evidence for TPBG Variants in Parkinson’s Disease Risk Across Global Ancestries
Objective: To evaluate ancestry-specific associations between common TPBG variants and Parkinson’s disease (PD) risk in the Global Parkinson’s Genetic Program (GP2). Background: The trophoblastic glycoprotein…
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