Anxiolytic-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) in rodent models of anxiety
Objective: The aim of this study was to assess the anxiolytic effects of istradefylline (KW-6002), an adenosine A2A receptor antagonist, in naive and anxiety-prone animals…Anxiety in patients with Parkinson’s disease
Objective: The aim of this longitudinal study is to examine which factors are associated with longitudinal changes in anxiety levels among individuals with Parkinson's disease…Diagnostic value of combined acute levodopa challenge and olfactory testing to predict Parkinson’s disease diagnosis
Objective: To evaluate the diagnostic value of combined acute levodopa challenge and olfactory testing to predict PD diagnosis. Background: Acute levodopa challenge can be used…Alpha-synuclein aggregates of cardiac sympathetic nerves in synucleinopathies and in neurologically unimpaired subjects. Correlation with sympathetic denervation
Objective: To study the cardiac sympathetic innervation and its relationship with the incidence of alpha-synuclein deposits in heart tissue of synucleinopathies and asymptomatic control patients.…Depression, anxiety, and apathy in Parkinson’s disease: Insights from neuroimaging studies
Objective: (1) To evaluate the existing neuroimaging studies of depression, anxiety and apathy in Parkinson's disease (PD) and (2) to determine the key neural pathway…Longitudinal assessment of sleep in an incident Parkinson’s disease cohort
Objective: To evaluate subjective and objective measures of sleep disturbance in an incident PD cohort over longitudinal follow-up. Background: Sleep disturbance is widely recognised as…Retinal nerve fiber layer thinning: A window into rapid eye movement sleep behavior disorders in Parkinson’s disease
Objective: To determine whether retinal structures are altered with the onset of rapid eye movement (REM) in Parkinson's disease (PD). Background: Rapid eye movement (REM)…Emotional valence and arousal ratings from rewarding and fearful stimuli are not influenced by levodopa in Parkinson’s disease
Objective: To analyze the effects of levodopa on affective ratings of emotional valence and arousal to rewarding, fearful and neutral stimuli in PD patients and…P100 latency of pattern reversal visual evoked potential and visual hallucination in Parkinson’s disease
Objective: To investigate whether P100 latency of pattern reversal visual evoked potential (PR-VEP) can predict the development of visual hallucination (VH) in Parkinson's disease (PD).…Impaired color discrimination selectively associates with postural instability and gait difficulties in Parkinson’s disease
Objective: To investigate the relationship between impairments of the cardinal motor impairments and color discrimination deficits in Parkinson's disease (PD). Background: Previous studies have shown…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.