α-synuclein aggregation and propagation in marmoset brains deteriorates its motor function
Objective: To confirm that α-synuclein aggregation and propagation in marmoset brains deteriorates its motor function. Background: Recently, the α-synuclein amyloid fibril is thought to be…Pharmacological modulation of lysosomal glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson’s disease
Objective: To study the pharmacological modulation of glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson's disease (PD). Background: PD is a complex neurodegenerative disorder…Variable selection using machine-learning to identify new signatures of patient-derived aggregated α-synuclein-induced neurodegeneration in non-human primates
Objective: Emerging evidence strongly suggests that α-synuclein, a major protein component of LB, may be responsible for the spreading of the pathological process within affected…Experimental rotenone model
Objective: To evaluat rotene model of parkinsonian syndrome in rats. Background: Rotenone is of highly lipophilic substances that can freely enter hematoencephalic barrier through and…Distinct Blood Leukocytes Expression Profiles of Long Non-coding RNAs and mRNAs in Parkinson’s disease patients
Objective: The study aims to identify the significant altered long non-coding RNAs (LncRNA) mRNAs expression profiles of blood leukocytes from Parkinson's disease (PD) patients, which…Nanoscale imaging reveals disorganization of the brain extracellular space in Lewy body-injected mice
Objective: To explore the brain extracellular space and its matrix at a nanometric scale in a context of α-synuclein-induced neurodegeneration. Background: The extracellular space (ECS)…Cell and animal models lacking RAB39B show biochemical and behavioural phenotypes that model aspects of Parkinson’s disease
Objective: To determine the pathogenic mechanisms underlying RAB39B-mediated Parkinson’s disease (PD). Background: PD is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the…Pupil evaluation as the test for the clinical manifestations of Parkinson’s disease
Objective: We clarify the correlation between abnormality in 123I-metaiodobenzylguanidine (MIBG) scintigraphy and task-evoked pupillary response in Parkinson's disease (PD) patients. Background: MIBG scintigraphy is one…The increased α-syn expression inhibits exosomal secretion
Objective: Exosomes, nano-sized extracellular vesicles, play an important role in many physiological processes in the central nervous system. Recently, we and others have demonstrated that…The Association between Infections and Parkinson Disease: A Systematic Review and Meta-analysis
Objective: Our study aimed to recapitulate and summarize the findings from the literature to provide an overview on the correlation between infection and PD. Background:…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.