Neurophysiological correlates of bradykinesia in Parkinson’s disease
Objective: In the present study we aimed to investigate whether objective measures of bradykinesia in Parkinson’s disease have any relationship with neurophysiological measures in primary…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: To characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD) subjects and compared to…Insulin degrading enzyme, a novel key protein against alpha-synuclein oligomers formation?
Objective: The objective of this work is to study the interaction between α-synuclein and the insulin degrading enzyme in the pancreas of subjects with synucleinopathies.…Salivary Alpha-Synuclein a new tool for the diagnosis of Parkinson’s disease?
Objective: The aim of the PARKSYN study was to test the utility of salivary alpha-synuclein (a-syn) concentration in the differential diagnosis between Parkinson's disease (PD)…Decreased amyloid-beta in patients with Idiopathic Parkinson’s Disease and white matter hyperintensities
Objective: The aim of this study is to investigate the clinical and biochemical profile of patients with PD with and without WMH. Background: Parkinson’s disease…GBA haploinsufficiency accelerated alpha synuclein pathology with altered lipid metabolism in a premotor model of Parkinson’s disease
Objective: To make Parkinson’s disease (PD) mice model and investigate the mechanism how glucocerebrosidase (gba) heterozygous mutations contribute to asyn pathology and development of PD.…Reduced vesicular storage of catacholamines enhance MPTP-induced death of dopaminergic neurons in locus coeruleus and olfactory bulb
Objective: In this study, we employed heterozygous knockout (vmat2+/-) mice to investigate the influence of reduced vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-impaired dopaminergic neurons…Status of riding bicycle and reasons for cessation of cycling in patients with Parkinson disease: A Japanese single center cross-sectional survey
Objective: To investigate the current status of riding bicycle and the reasons for cessation of cycling in patients with Parkinson disease (PD). Background: The “bicycle…T lymphocytes in Parkinson’s disease pathogenesis and therapy: A systematic review
Objective: A systematic literature review was conducted to synthesize the current state of knowledge on the role of T lymphocytes in Parkinson’s disease (PD) pathology…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.