F1 crossbreds of C57BL/6 and CD-1 mice demonstrate resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced nigral neurodegeneration
Objective: To establish the neural basis of varying susceptibility to MPTP in MPTP resistant CD-1 mice, susceptible C57BL/6 mice and their crossbreds; simulating the variable…Involvement of peripheral immune system in the pathogenesis of Parkinson’s disease
Objective: To investigate the role of peripheral immune system in the pathogenesis of Parkinson's disease carrying LRRK2 risk variants. Background: Leucine-rich repeat kinase 2 (LRRK2)…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…An exuberant cortical γb influences the unmasking and intensity of dyskinesia in 6-OHDA-treated freely-moving rats
Objective: To clarify the pathogenetic role of Beta band (βb) and Gamma band (γb) in 6-OHDA-treated freely-moving rats, by combining histochemical and electrophysiological investigations. Background:…Dynamic and static posturographic analysis among fallers and non- faller Parkinson’s disease (PD) patients using Neurocom SMART EquiTest
Objective: The purpose of this investigation is to study both the sensory and motor aspects of voluntary and automatic postural control using static and dynamic…Evaluation of regional changes in striatal DAT binding in a progressing Parkinson’s disease (PD) cohort: Lessons for imaging biomarker assessment in disease-modifying therapeutic trials
Objective: To evaluate subregion-dependent striatal changes in dopamine transporter (DAT) binding using 123-I Ioflupane SPECT in PD participants in the Parkinson Progression Marker Initiative (PPMI)…Alpha synuclein and crystallin expression in human lens in Parkinson’s disease
Objective: To determine the Protein Profile of cataract lenses in Parkinson's disease (PD). Background: Protein accumulation, mainly αB-crystallin, in the lens causes cataract. PD is…α-synuclein CSF levels correlate with urinary dysfunction in early de novo Parkinson’s disease patients
Objective: To explore the association between levels of α-synuclein burden and urinary dysfunction in early de novo (untreated) Parkinson's disease (PD) patients. Background: Urinary dysfunction…Discrimination of Parkinson’s disease participants from healthy controls using telephone-quality voice recordings
Objective: To test the practicality and efficacy of telephone-quality voice recordings to discriminate Parkinson's disease (PD) participants from healthy controls (HC). Background: Vocal performance degradation…The effect of STN-DBS on movement initiation control is modulated by the noradrenergic system: Evidence of an interaction from a combined pharmacological/DBS/EEG study
Objective: Assessing the role of the noradrenergic system underlying the effect of subthalamic nucleus stimulation (STN-DBS) on akinesia. Background: Slowness in movement initiation, associated with…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.