Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…Changes in serum amino acid levels with progression of Parkinson’s disease
Objective: The purpose of this study was to analyze changes in serum amino acid profile with progression of Parkinson's disease (PD). Background: PD is a…Investigating the role of Parkin in mitigating oxidative stress
Objective: We are investigating the ability of Parkin protein to protect cells from oxidative stress (OS) and the mechanisms that underlie this function. We hypothesize…Clinical predictors of airway protective dysfunction in Parkinson’s disease
Objective: The goal of this study was to test the sensitivity and specificity of several airway protective and disease-specific factors for predicting swallowing safety in…Disease severity is not predictive of the dose required for apomorphine sublingual film (APL-130277) to convert a patient with Parkinson’s disease from OFF to fully ON
Objective: Evaluate whether baseline disease severity is predictive of the effective APL-130277 dose to turn a patient with Parkinson's disease (PD) from OFF to fully…Treatment of OFF episodes in Parkinson’s disease: An evaluation of patient and caregiver insights
Objective: Evaluate patient and caregiver opinions into the treatment of OFF episodes in patients with Parkinson's disease (PD). Background: OFF episodes are fairly common in…Treatment of OFF episodes in Parkinson’s disease: An evaluation of physician practices
Objective: Determine physician practices into the treatment of OFF episodes in patients with Parkinson's disease PD. Background: OFF episodes are fairly common in patients with…Enteric neurons reveal substantial in vivo mitochondrial changes in Parkinson’s disease
Objective: Study in vivo mitochondrial and ganglionic morphometrics of enteric neurons in Parkinson's disease. Background: While well established in autopsy studies, the crucial role of…Detection of leucine-rich repeat kinase 2 in human biofluids
Objective: To evaluate the presence of leucine-rich repeat kinase 2 (LRRK2) in human biosamples, including cerebrospinal fluid (CSF) and urine, as a first step towards…The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies
Objective: Rhes is a small GTP-binding protein highly enriched in the striatum, developmentally regulated by thyroid hormone, and by dopamine (DA) innervation in adult rat…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.