Impaired stress-induced mitophagy in parkinsonian LRRK2(R1441G) knockin mutant mice
Objective: 1. Morphological changes and accumulation of ubiquitinated mitochondria in the striatum of aged leucine-rich-repeat kinase 2 (LRRK2)R1441G knockin mutant mice (Liu et al., 2014,…Serum soluble transferrin receptor levels correlate with the Hoehn & Yahr stage of Parkinson disease progression
Objective: To test whether levels of soluble transferrin receptor (sTfR) in the serum of Parkinson disease (PD) patients are correlated with the progression of the disease…Role of the subthalamic nucleus and globus pallidus internus in response inhibition during masked prime tasks in human
Objective: To study the subthalamic nucleus (STN) and globus pallidus internus (GPi) local filed potential (LFP) activities in the response inhibition during masked prime tasks…Regulation of aberrant striatal oscillations by glutamate receptor blockade in parkinsonian non-human primates
Objective: To study the abnormal striatal oscillations and regulation of striatal oscillatory activities by micro-infusion of glutamate receptor antagonist in the non-human primate model of…Metabolic syndrome: Its link with motor function of Parkinson’s disease (PD)
Objective: To evaluate if metabolic risk factors can affect the motor function of PD patients Background: The etiology of PD remains unclear. It has been…Firing rate and proportion of subthalamic oscillatory neurons increase associated with more advanced Parkinson’s Disease
Objective: To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with…Modeling Parkinson’s disease pathology by combined injection of fibrilar and monomeric α-synuclein in rat brain
Objective: Development of a fast and progressive Parkinson’s disease (PD) model in rat Background: α-Synuclein is a common link between sporadic and familial PD. Rodent…Gait disturbance and olfactory dysfunction is associated with central cholinergic dysfunction in early Parkinson’s disease
Objective: We hypothesis that olfactory dysfunction, could be an independent predictor of gait disturbance in early PD. Background: The pathophysiology of gait disturbance is not fully…Brain insulin resistance in Parkinson’s disease
Objective: To test the hypothesis that brain insulin resistance (i.e. decreased insulin/insulin like growth factor (IGF)-1 signaling) occurs in the substantia nigra pars compacta (SNc)…Analysis of serum non-mercaptoalbumin in patients with Parkinson’s disease
Objective: It is well known that the oxidative stress might be associated with the pathomechanisms of Parkinson’s disease (PD). In this study, we assessed serum…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.