The effects of dual task on the finger tapping performance of Parkinson’s disease.
Objective: In the present study, we aim to analyze the effects of a dual task on repetitive finger tapping (FT) performance in patients with Parkinson’s…Potential of non-invasive brain stimulation to ameliorate freezing of gait in Parkinson’s disease: A deep repetitive TMS randomized, double-blinded, cross-over pilot study
Objective: To investigate the impact of deep transcranial magnetic stimulation (TMS) of the medial prefrontal cortex (mPFC) on freezing of gait (FOG) in Parkinson’s disease…Neuroinflammation in the substantia nigra is triggered by synucleinopathy and precedes nigral degeneration
Objective: To determine the relationship between synucleinopathy, neuroinflammation and nigrostriatal degeneration using the rat α-syn PFF model. Background: No therapy exists to halt or slow…Characterizing the Bcl-2 Associated Athanogene 5 Interactome
Objective: Characterizing the Bcl-2 Associated Athanogene 5 (BAG5) interactome will uncover the molecular pathways with which BAG5 associates and further elucidate its role in dopaminergic…Neuroprotective Potency of Tetrahydroisoquinoline a Novel Ayurveda Molecule in Experimental Parkinson’s Disease
Objective: Tetrahydroisoquinoline (TIQ) an identified alkaloid from ancient Indian ‘Ayurveda’ medicine for Parkinson’s disease (PD) was tested for neuroprotection in a cellular system and a…Alpha-synuclein enhances histone H3 lysine-9 dimethylation
Objective: To explore the nuclear function of alpha-synuclein (αS). Background: αS is a protein linked to Parkinson’s disease (PD) and related neurodegenerative disorders. It is…Extracellular alpha-synuclein internalizes into cells by hijacking endocytic trafficking of dopamine transporter
Objective: The main purposes of this study were to: 1) investigate the possible effect of extracellular alpha-synuclein (aSYN) on the endocytic rate of dopamine transporter…New device HANABI (HANdai Amyloid Burst Inducer) is a rapid and sensitive detecting system of α synuclein fibril in CSF from Parkinson’s disease patients
Objective: Early diagnosis for PD is disturbed by the lack of sensitive and objective detection of accumulated αSyn in the patient’s brain. Recently, Real-Time Quaking-Induced…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…Interaction between PLK2 ( Polo-like kinase-2) and alpha-synuclein in the non-human primate MPTP model of Parkinson disease
Objective: The objective is to determine the levels and interactions between PLK2 and one of its main substrates, synuclein, in the non-human primate MPTP model of…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.