Longitudinal study of freezing of gait in patients with Parkinson’s disease
Objective: We conducted a prospective hospital based cohort study to investigate the incidence of Freezing of gait (FOG) and variables associated with onset of FOG…Axial signs in early-stage Parkinson’s disease : an influence of the genotype ?
Objective: To assess the association between the genotype and the axial signs. Background: Regarding the onset of axial signs in Parkinson’s Disease (PD), heterogeneity has…Mutant DNAJC13 modulates accumulation and toxicity of alpha-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease
Objective: The aim of this study is to investigate the effect of DNAJC13 mutation on the vesicle transport, α-synuclein (αSYN) distribution/catabolism, and neurodegeneration using a…Disease-modification in Translational Models of Parkinson’s disease by the Rho Kinase Inhibitor Fasudil
Objective: To evaluate the therapeutic potential of the Rho Kinase (ROCK) inhibitor Fasudil in translational models of Parkinson’s disease (PD). Background: There is still a…The novel Parkinson´s disease locus RIT2 and alpha-synuclein function in intersecting pathways
Objective: We aim to describe the molecular pathways at the crossroad of etiology and susceptibility in PD, focusing on Rin, coded by the recently associated…Increased and symmetric expression of rigidity in early Parkinson’s disease with abnormal REM sleep without atonia
Objective: The purpose of this study was to compare the level and bilateral expression of upper arm rigidity between people with early stage Parkinson’s disease…Fundamental limit of the alpha-synuclein immunohistochemistry using the endoscopic biopsy from the gastrointestinal tract as a biomarker for Parkinson disease: a case-control study
Objective: To investigate significance of the Lewy pathology in biopsy and surgical specimen in the gastrointestinal (GI) tract as an in-vivo biomarker for Parkinson disease (PD). Background: Alpha-synuclein…The nature of postural tremor in Parkinson’s disease
Objective: To identify dopaminergic mechanisms underlying postural tremor in Parkinson's disease. Background: Parkinson’s tremor classically occurs at rest, but many patients also have a postural…GBA mRNA is diminished in brain and blood of Lewy body diseases
Objective: To find out whether GBA deficiency starts at the transcriptional level and if it also involves alternative splicing. To study GBA expression changes in…Does cerebellar dysfunction contribute to tremor in Parkinson’s disease?
Objective: This study aims to investigate the potential role of cerebellar dysfunction in the pathogenesis of tremor in Parkinson’s disease (PD). Background: Rest tremor in…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.