Ultra high field magnetic resonance imaging of nigrosome 1 is a biomarker of new onset and premotor Parkinson’s disease
Objective: An unmet need exists to develop a methodology to diagnose Parkinson's disease (PD) in the premotor stage, so that patients can be enrolled in…Intraoperative localization of beta band and high-frequency oscillations within the subthalamic nucleus
Objective: To investigate whether beta band activity (13-30Hz) and high-frequency oscillations (150-400Hz) arise from the same spatial location within the subthalamic nucleus (STN) of Parkinson's…The patient’s perspective: The effect of dopamine on Parkinson symptoms
Objective: To investigate the correlation between patient-based vs. clinician-based L-Dopa effects on PD symptoms in tremor-dominant patients. Background: Medication adjustments are often solely based on…Detecting brainstem changes in Parkinson’s disease using quantitative MRI
Objective: 1. Can brainstem changes be detected using quantitative MRI (qMRI). 2. How many subjects would be required to detecting changes in brainstem regions affected…Critical path for Parkinson’s II: Global regulatory agencies support the use of dopamine transporter neuroimaging as an enrichment biomarker to enable clinical trials in early Parkinson’s disease
Objective: This presentation focuses on neuroimaging of the Dopamine Transporter as an enrichment biomarker in clinical trials of Parkinson's disease (PD). Background: The Critical Path…Improvement of saccade amplitude by the STN DBS and visual target eccentricity
Objective: To investigate whether or not the improvement of saccade amplitude by the subthalamic nucleus (STN) deep brain stimulation (DBS) is the same for to…Neuromelanin-MRI of substantia nigra subregions in Parkinson’s disease
Objective: To detect changes in the different subregions of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and to correlate the…Spectral analysis of rapid eye movement (REM) sleep as a potential marker of neurodegenerative disease in REM sleep behavior disorder
Objective: To investigate whether spectral analysis at baseline in rapid eye movement (REM) sleep can differentiate patients with REM sleep behavior disorder (RBD) who will…Impact of chronic LD treatment on metabolism, blood flow and blood-brain barrier permeability in the 6-OHDA rat model
Objective: To determine the effects of chronic LD treatment and induction of dyskinesias on cerebral metabolism, blood flow and blood-brain barrier permeability in 6-OHDA rat…Multi-modal imaging in Parkinson’s disease patients with freezing of gait
Objective: The objective of the current study is to refine understanding of the pathophysiological mechanisms underlying freezing of gait (FOG) in Parkinson's disease (PD) using…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.