Real-life accelerometer-based detection of DBS effects on tremor and dyskinesia in Parkinson’s disease, trained with ecological momentary assessments
Objective: To detect real-life tremor and dyskinesia fluctuations, using naturalistic wearable data for prediction, and ecological momentary assessments (EMA) data for model training. Background: Parkinson’s…DTI-ALPS Insights into Glymphatic Dynamics and Neurovascular Changes in Parkinson’s Disease
Objective: To investigate glymphatic activity, structural small vessel disease (SVD) markers, and white matter microstructure in Parkinson’s disease (PD) patients, and to explore their associations…Metabolic Syndrome is not Associated with Parkinson’s Disease Severity, but Individual Metabolic Components May Be
Objective: To investigate whether individual metabolic components are associated with motor, cognitive, and functional outcomes in Parkinson’s disease (PD). Background: Metabolic syndrome has been proposed…Evaluation of Cardiac Markers and Clinical Metrics in Friedreich’s Ataxia
Objective: To evaluate cardiac specific markers and clinical metrics associated with Friedreich’s Ataxia (FA) and FA cardiomyopathy severity and progression. Background: Friedreich’s Ataxia is a…Multilingual Smartphone Application for Objective Motor Assessment in Parkinson Disease: Cross-Sectional Clinical Validation Study
Objective: To assess the clinical validity of an Android-based application for remote, objective quantification of tremor and hand bradykinesia (2D) in Parkinson’s disease against reference-standard…The Alternating Finger Tapping Test Poorly Predicts Real-World Daily Activity Performance in Parkinson’s Disease
Objective: To evaluate hand dexterity and daily hand task performance in individuals with PD and investigate the predictive validity of dexterity testing for functional impairment…Sleep Patterns and Cognitive Function in Parkinson’s Disease: a Longitudinal Pilot Study
Objective: To evaluate the feasibility and usability of a commercially available wearable device for long-term monitoring of sleep patterns in Parkinson’s disease (PD) and how…MLR–cerebellar network in body-first vs. brain-first PD: functional connectivity and clinical correlation with gait impairment
Objective: This study aims to clarify subtype-specific changes in mesencephalic locomotor region (MLR)-cerebellar functional connectivity(FC)[1][2] between body-first and brain-first Parkinson’s disease (PD) patients[3][4], and to further characterize…Simultaneous EEG and Pallidal Local Field Potential Recording in the Diagnosis of Paroxysmal Movements in a Patient with PDE2A Mutation
Objective: To describe the diagnostic value of pallidal local field potentials in distinguishing movement disorder from seizure in a complex phenotype. Background: Sensing-capable deep brain…Safer AI Dosing Recommendations in Parkinson’s Disease Through Uncertainty-Adaptive Prediction
Objective: To develop and validate a uncertainty-adaptive AI framework to improve the safety and clinical utility of levodopa dose predictions by explicitly flagging high-risk, ambiguous cases…
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