Understanding the Earliest Phases of Parkinson’s disease: An Update on the Prodromal Effort Within the Global Parkinson’s Genetics Program
Objective: To continue recruitment of global ‘at-risk’, early and prodromal Parkinson’s disease (PD) cohorts to the Global Parkinson’s Genetics Program (GP2, http://gp2.org/), support existing cohorts…Upper Limb Coordination During Walking is Associated with Clinical Severity in Parkinson’s Disease
Objective: To explore the clinical relevance of upper limb coordination in PD, measured by wearable sensors, and quantified using continuous relative phase (CRP). Background: Upper…Reduced Glucocerebrosidase Activity Is Associated with Cognitive Decline in Severe GBA1-Associated Parkinson’s Disease
Objective: To analyse glucocerebrosidase (GCase1) activity in GBA1-PD patient-derived fibroblasts and blood and to compare it with sporadic PD (sPD) and controls at baseline and…Functional Movement Disorders in a Public Health System: Misdiagnosis, Diagnostic Delay, and Healthcare Utilization in 61 Patients
Objective: To characterize diagnostic delay, patterns of misdiagnosis, and healthcare utilization before diagnosis of FMD in patients evaluated in a tertiary public hospital in Peru.…18F-FD4 PET Reveals α-Synuclein Deposition and Clinical Correlations in Parkinson’s Disease
Objective: This study aimed to determine the potential of a novel α-syn tracer, 18F-FD4 PET, to track regional α-synuclein deposition in PD and explore its…Characteristics of Cortical Beta Bursts in Parkinson’s disease
Objective: 1. Do patients with PD experience changes in cortical beta bursts in both the low and high β frequency bands?2. Are bursts of different…Agreement Between Patient-Reported Experiences of Daily Living and Clinician-Rated Motor Exam Severity in Parkinson’s Disease
Objective: To assess concordance between patient-reported experiences of daily living and clinician-rated motor exam severity in Parkinson’s disease (PD). Background: Clinicians rate PD motor severity…Identification of Parkinson’s Disease Tremor-Related Functional Network Topographies Using 3.0 T rs-fMRI
Objective: To identify rs-fMRI-derived functional brain network patterns associated with parkinsonian tremor severity and dopaminergic medication responsiveness in Parkinson’s disease (PD). Background: While metabolic imaging…How Common Is Central Pain in Parkinson’s Disease? A Systematic Review and Meta-Analysis
Objective: This systematic review and meta-analysis sought to determine the prevalence of central pain in Parkinson's disease (PD) and examine its impact on patients' quality…Baseline Characteristics of Participants Enrolled in a Randomised Pilot Study of Enhanced Tai Chi for Parkinson’s disease
Objective: To describe the baseline characteristics of participants enrolled in a pilot randomised controlled study evaluating Enhanced Tai Chi for Parkinson’s disease (NCT07297368). Background: Exercise-based…
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