Development and initial feasibility of a Randomised Pilot Trial of Enhanced Tai Chi for Parkinson’s Disease
Objective: To describe the design and feasibility of a randomised controlled pilot study evaluating an Enhanced Tai Chi intervention for people with Parkinson’s disease (NCT07297368).…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Improvement of Wearing‑Off Symptoms After Initiation of COMT Inhibitors in Parkinson’s Disease patients with early motor fluctuations: Results from the 12 months interim analysis of REONPARK Study
Objective: The REONPARK study is an observational study conducted in Spain aiming to evaluate COMT inhibitors (iCOMT) effectiveness and tolerability in alleviating motor complications associated…A Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Fluid Biomarkers in Parkinson’s Disease
Objective: Analyze current efforts and quality of fluid and tissue biomarkers in Parkinson’s Disease (PD) to offer insight into their utility for diagnosis vs healthy controls (HC). Background: Alpha-synuclein is emerging as the leading biomarker…Monitoring of Motor Complications with Wearable Technology in Parkinson’s Patients Considered for Deep Brain Stimulation
Objective: To evaluate the contribution of a digital biomarker to the identification of motor complications in patients with Parkinson’s disease (PD) being considered for deep…Temporal Prediction and Multisensory Integration in Musician’s Dystonia
Objective: We aimed to determine whether temporal prediction and multisensory integration are altered in musician’s dystonia (MD) and whether task-specific visual, auditory, and audiovisual cues…Move-Brain-PD: a Randomized Multicenter Protocol of Remotely Monitored Home-based Aerobic Exercise for Parkinson’s Disease Patients with Mild Cognitive Impairment
Objective: To describe the rationale and design of Move-Brain-PD, a randomized multicenter study evaluating whether remotely monitored home-based aerobic exercise improves cognition and motor symptoms…Unraveling Kinase-Phosphatase Dysregulation in Parkinson’s disease Peripheral Blood Mononuclear Cells Through Targeted Transcript Analysis
Objective: To probe kinase-phosphatase dysregulation and peripheral biomarker potential in peripheral blood mononuclear cells (PBMCs) via LRRK2 (kinase), PPM1H and PP2A (phosphatases), LC3 (autophagy), and…Stimulation-Induced Laryngospasm During Awake Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor
Objective: To report a rare case of acute laryngospasm during intraoperative stimulation in VIM-DBS surgery. Background: Deep brain stimulation (DBS) of the ventral intermediate nucleus…Baseline Characteristics of Participants Enrolled in a Randomised Pilot Study of Enhanced Tai Chi for Parkinson’s disease
Objective: To describe the baseline characteristics of participants enrolled in a pilot randomised controlled study evaluating Enhanced Tai Chi for Parkinson’s disease (NCT07297368). Background: Exercise-based…
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