Age-Dependent Peripheral Dissemination of α-Synuclein Seeds: Mechanistic Basis for Blood-Based Early Detection of Parkinson’s Disease
Objective: To evaluate the diagnostic utility of serum α-synuclein (α-Syn) seed amplification assay (SAA) for early PD detection using preformed fibril (PFF)-induced mouse models and…Smartphone-Based Multilingual Application for Remote Screening and Monitoring of Motor Symptoms Associated with Parkinson’s Disease
Objective: This project, funded by the Department of Science and Technology, West Bengal, aims to develop a smartphone-based system for remote screening and monitoring of…Dysphagia and Oropharyngeal Freezing in Progressive Supranuclear Palsy
Objective: To investigate the characteristics and mechanism of dysphagia in patients with Progressive Supranuclear Palsy(PSP). Background: Up to 79% of patients with PSP suffer from…IMU Insole-Derived Gait Digital Biomarkers in idiopathic RBD and Parkinson Disease
Objective: To identify IMU insole-derived gait biomarkers differentiating healthy controls (HC), idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson disease (PD) during a…Development and initial feasibility of a Randomised Pilot Trial of Enhanced Tai Chi for Parkinson’s Disease
Objective: To describe the design and feasibility of a randomised controlled pilot study evaluating an Enhanced Tai Chi intervention for people with Parkinson’s disease (NCT07297368).…Explainable Machine-Learning Risk Stratification to Identify High-Potential Physical Therapy Responders with Freezing of Gait in Parkinson’s Disease
Objective: To develop an interpretable machine-learning model to predict freezing of gait (FOG) and identify Parkinson’s disease (PD) patients most likely to benefit from physical…Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia
Objective: Chronic treatment of L-DOPA causes dyskinesia (LID) in PD patients. We aim to understand LID from a lipid-metabolism perspective and identify novel therapeutic targets.…SGCE Mutations in Chinese Dystonia Patients: A Dual-Center Sequencing Study and Literature Review
Objective: To delineate the clinical and genetic profiles of dystonia patients with SGCE mutations in the Chinese population. Background: SGCE mutations are the primary cause of…Acute Microstructural Imaging of Focused Ultrasound Thalamotomy Lesions is Associated with Long-Term Tremor Relief in Essential Tremor
Objective: To determine whether restricted diffusion imaging (RDI) 30 minutes after MR-guided focused ultrasound (MRgFUS) thalamotomy in patients with essential tremor (ET) improves the association…Investigating Mitochondrial Integrity in Spinocerebellar Ataxia Type 12 via Patient-Derived iPSC Models
Objective: This study aims to establish patient-derived induced pluripotent stem cell (iPSC) models of Spinocerebellar Ataxia Type 12 (SCA12) and investigate mitochondrial transcriptional alterations across…
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