Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson’s disease.The AMBITIOUS Study Protocol
Objective: To determine in Parkinson’s disease (PD) patients carrying GBA mutation the role of Ambroxol (ABX) on the progression of cognitive performance (primary aim), motor…Prevalence and severity of non-motor symptoms in hispanic at-risk population with REM-sleep behavior disorder.
Objective: To detect non-motor symptoms in individuals at-risk for Parkinson's disease (PD) due to idiopathic REM sleep behavior disorder (RBD) and determine the rate of…Feasibility and acceptability of implementing dignity therapy as a supportive intervention for people with movement disorders.
Objective: To determine the feasibility and acceptability of implementing Dignity Therapy (DT) in a neuropalliative clinic, and to determine preliminary efficacy. Background: Awareness of the…Safety profile of pimavanserin therapy in elderly patients with neurodegenerative disease-related neuropsychiatric symptoms: a Phase 3b study
Objective: To evaluate the safety profile of pimavanserin in patients with neuropsychiatric symptoms related to neurodegenerative disease (NDD). Background: Patients with NDD including Parkinson’s disease…Determinants of care partner burden in atypical parkinsonian syndromes
Objective: To understand the determinants of burden among people caring for individuals diagnosed with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), or multiple system atrophy…Connectomics of Chronic VIM vs Rescue VIM/VO Deep Brain Stimulation in Essential Tremor
Objective: This study aims to use connectomic analysis to determine the difference between fiber pathway activation in patients with ineffective VIM stimulation and effective VIM/VO…Late Onset Cerebellar Ataxia in a Patient with a Heterozygous Pathogenic KIF1A Mutation: A Case Report
Objective: Expand upon the current phenotypic understanding of those with KIF1A-associated neurological disorder (KAND), including late onset progressive cerebellar ataxia (CA). Background: KAND encompasses a group…The High Prevalence of Developmental Vascular Anomalies in Parkinson’s Disease using USPIO-based MICRO MRI
Objective: To improve cerebral vascular visibility using an ultra-small super-paramagnetic iron oxide (USPIO) contrast agent and identify vascular abnormalities in patients with Parkinson’s disease (PD).…Movement disorders spectrum in CTNNB1-related neurodevelopmental disorders
Objective: To describe the phenomenology and clinical course of movement disorders in CTNNB1-related neurodevelopmental disorder (CTNNB1-NDD). Background: CTNNB1-NDD is a rare neurogenetic condition caused by…Presenting the Dystonia Pain Classification System (Dystonia-PCS)
Objective: To develop a chronic pain (CP) classification and scoring system for dystonia. Background: CP is prevalent in dystonia and significantly impacts patient’s quality of…
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