Deep Brain Stimulation in Parkinson’s Disease: real-world outcomes at a single centre
Objective: To describe the clinical outcomes in PD patients following DBS and analyse whether certain demographic and clinical factors are associated with poor outcomes. Background:…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…Accelerated longitudinal brain atrophy in the ‘diffuse malignant’ Parkinson’s disease subtype
Objective: To investigate differential pattern of brain atrophy between Parkinson’s disease (PD) clinical subtypes using longitudinally acquired brain magnetic resonance imaging (MRIs). Background: Parkinson’s disease…Stiff-Person Syndrome: Diagnosis and Experimental Models
Objective: Locked-in syndrome is a syndrome that is characterized by the lack of an adequate response of the patient to external, including verbal, stimuli due…Pain and sleep in Parkinson’s disease
Objective: Pain and sleep disturbances are among the most frequently encountered non-motor symptoms in Parkinson’s disease (PD). Background: The aim of this study was to…A randomized, phase 2a, double-blind, placebo-controlled clinical trial with NE3107 adjunctive to carbidopa/levodopa in patients with Parkinson’s disease
Objective: To evaluate the motor effects of NE3107 treatment in patients with levodopa-treated Parkinson’s disease (PD) experiencing motor fluctuations. Background: NE3107 is an oral, blood-brain…Reductions in OFF time with ND0612 for patients with Parkinson’s disease experiencing motor fluctuations: Responder-analysis from an open-label Phase 2 study
Objective: Evaluate the efficacy of subcutaneous levodopa/carbidopa infusion with investigational ND0612 in reducing OFF time in people with Parkinson’s disease (PwP) experiencing motor fluctuations. Background:…“Grab-the-lock test “ – A novel clinical test for identification of dorsolateral Subthalamic nucleus [STN] during deep brain stimulation [DBS]
Objective: The target during STN DBS for Parkinson’s disease is the dorsolateral STN which plays a major role in motor functions in contrast to the venteromedial…A human tissue engineered nigrostriatal system as a testbed for understanding PD pathophysiology and therapeutic development
Objective: The objective of these studies is to develop a tissue engineered nigrostriatal system involving human dopaminergic and striatal cells to recapitulate many of the…Microbiota and Gastrointestinal Manifestations of Parkinson’s Disease with Arabic Translation of Gastrointestinal Dysfunction Scale
Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut…
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