Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut microbiota in PD patients in comparison to healthy controls.

Background: Gastrointestinal manifestations are among the most common and annoying non-motor symptoms of Parkinson’s disease (PD).

Method: 30 PD patients and 30 matched controls were assessed using validated Arabic version of gastrointestinal dysfunction scale for PD (GIDS-PD) and gut microbiota analysis was done by using 16S rRNA sequencing.

Results: There was statistically significant difference between PD patients and control group as regard frequency, difficulty of passing stools, experiencing hard stools, difficulty in swallowing (p>0.001). There were no significant differences in the relative abundance of the fecal microbiota in PD patients and controls. However, microbes associated with gut permeability and inflammation were found to be marginally altered in PD patients.

Conclusion: The current study validated the Arabic version of GIDS-PD and showed higher prevalence gastrointestinal symptoms among PD patients that was correlated to motor and non-motor symptoms and negatively impacted patients’ QoL. Further studies are required to characterize microbiota in Egyptian PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/microbiota-and-gastrointestinal-manifestations-of-parkinsons-disease-with-arabic-translation-of-gastrointestinal-dysfunction-scale/