Severity of Motor Symptoms Correlates with Asymmetric Changes in Globus Pallidus Internus and Caudate Nuclei in Parkinson’s Disease
Objective: Explore the relationship between MDS-UPDRS motor sub-scores (MDS-UPDRS-III) and cerebral perfusion in different Regions of Interest (ROI) in patients with Parkinson’s disease (PwP). Background:…Decrease in Walking Ability with Increased Functional Connectivity between Multiple Brain Areas in Parkinson’s Disease
Objective: To compare the functional connectivity of PFC, PMC, and PSC regions during walking between individuals with Parkinson's disease and healthy controls. Background: Gait disturbances…Opicapone Effect on Sleep Disorders in Fluctuating Parkinson’s Disease Patients: Findings from the OASIS Trial
Objective: The OASIS exploratory trial aimed to evaluate the effects of opicapone (OPC) on sleep disorders in Parkinson’s disease (PD) patients with motor fluctuations (MF)…A Phase 2 Randomized Clinical Trial of TAK-071, an Acetylcholine M1 Receptor Positive Allosteric Modulator, in Parkinson Disease with Cognitive Impairment
Objective: To study the safety and efficacy of TAK-071, an M1 positive allosteric modulator, in adults with Parkinson disease (PD) with increased risk for falls…Effect of Istradefylline on Motor and Non-motor Symptoms in Patients with Parkinson’s Disease: the ISTRA ADJUST PD Randomized, Controlled Study
Objective: To examine the effects of istradefylline on motor and non-motor symptoms in Parkinson’s disease (PD) patients with wearing-off phenomena. Background: Previous results [1,2] of…MRI Predictive Marker of the Vestibular Galvanic Stimulation Effectiveness in the Postural Instability Treatment in Parkinson’s Disease.
Objective: To assess the galvanic vestibular stimulation (GVS) effect on axial symptoms and cervical vestibular evoked myogenic potential (cVEMP) depending on the Magnetic Resonance Parkinsonism…Machine Learning Model Comparison for Freezing of Gait Prediction in Advanced Parkinson’s Disease Patients
Objective: This study compares the performance of machine learning classification models in predicting freezing of gait (FoG) from instrumented stand-and-walk trials in advanced Parkinson’s disease…Ultrasound of Spinal Fluid Dynamics in Headache and Vertigo Patients with Central Sensitization: Novel Biomarker
Objective: This study aimed to investigate the neurophysiological responses and potential mechanisms underlying the therapeutic effects of ultrasound (US)-guided dry needling in patients presenting with…24 Hour Maxillofacial Administration of Levodopa in a Parkinsons Patient -An Alternative Route of Administration in Parkinsons Disease
Objective: To assess tolerability, feasibility, safety and to assess outcome measures clinically as well as by serum levels over 24 hours, using the alternative maxillofacial…Dopaminergic Adverse Events With 24-hour Subcutaneous Infusion of ND0612
Objective: Characterize dopaminergic treatment-emergent adverse events (TEAEs) reported with 24h ND0612 treatment in clinical studies. Background: Dopaminergic adverse events are commonly reported across the spectrum…
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