The Effect of Subjective Postural Vertical on Forward Flexed Posture in Parkinson’s disease
Objective: The present study prospectively tested the effects of the subjective postural vertical on the exacerbation of the forward flexion of trunk (FFT) through long-term…Functionality Analysis of Immunoregulatory Cells Stimulated with Dopaminergic Agonists in People Living with Parkinson’s Disease
Objective: To evaluate the effect of dopaminergic agonists (DA) on the activation and functionality of regulatory cells in People living with Parkinson's Disease (PwP). Background:…REGENERATE-PD: A Phase 2, Randomized, Double-Blind, Surgery-Controlled Study of GDNF Gene Therapy (AAV2-GDNF; AB-1005) for Moderate Stage Parkinson’s Disease
Objective: To present the REGENERATE-PD study design: a phase 2, randomized, double-blind, surgery-controlled trial assessing efficacy and safety of intraputaminal adeno-associated virus serotype 2 containing…IGF2 Induce Neuroprotection in PD Preclinical Models by Modulation of Immune Response.
Objective: We propose to determine a therapeutic strategy based on adoptive transfer of macrophages reprogrammed for recombinant IGF2 (rIGF2) treatment in PD preclinical model. Background:…Regional Brain Volume Differences Across PD Clinical Subtypes
Objective: To investigate brain morphometric differences across Parkinson disease (PD) clinical subtypes. Background: We developed a PD subtype classification with three subtypes that includes motor…Comparison of Spontaneous Brain Activity in Distinguishing Parkinsonian Variant of Multiple System Atrophy from Parkinson’s Disease at Early Stage
Objective: The primary objective was to explore distinctions in the fractional amplitude of low-frequency fluctuation (fALFF) indicator among early-stage parkinsonian variant of multiple system atrophy…Pure Autonomic Failure As a Severe “Body-First Subtype” of Lewy Body Disease: A Multimodal Imaging Study of the Autonomic Nervous System
Objective: Using multi-modal imaging this study aimed to characterize the deterioration of the parasympathetic and sympathetic nervous system in pure autonomic failure (PAF) in comparison…Increased Brain-Age Gap Estimate (BrainAGE) in Neurological Wilson Disease
Objective: To assess grey matter (GM) volume derived brain-aging in Wilson Disease (WD) using a previously proposed machine learning (ML) algorithm. Background: GM atrophy is…Exploring the Neuroprotective Effects of Diurnal Light Exposure in Early-Stage Parkinson’s Disease: A Longitudinal, Multi-Sensory Intervention Study
Objective: This study aims to explore the neuroprotective effects of controlled diurnal light exposure on neurodegeneration rates in early-stage PD patients, positing that light therapy…Centralizing brain tissue donation for a large multi-site Parkinson’s disease (PD) study
Objective: Brain tissue analysis is an invaluable resource to better understand PD progression, but there is limited access to this resource and swift postmortem collection…
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