Sex comparisons for co-pathologies and clinical phenotypes in autopsy-confirmed four-repeat tauopathies
Objective: To assess whether co-pathologies and clinical phenotypes in people with four-repeat tauopathies (progressive supranuclear palsy [PSP], corticobasal degeneration [CBD]) differ by sex. Background: PSP…Presence of Common Psychiatric Diagnoses Did Not Impact the Efficacy or Safety of Ecopipam in Individuals With Tourette Syndrome
Objective: To evaluate ecopipam efficacy/safety in individuals with Tourette syndrome (TS) with or without common psychiatric comorbidities. Background: Co-occurring psychiatric conditions are frequently observed with…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Urine and Plasma Bis(monoacylglycero)phosphate (BMP) in Asian LRRK2 p.G2385R and p.R1628P Variant Carriers with Parkinson’s Disease
Objective: To compare urine and plasma bis(monoacylglycero)phosphate (BMP) levels in Parkinson disease (PD) patients carrying Asian-prevalent LRRK2 variants (p.G2385R, p.R1628P) against idiopathic PD (iPD) and…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…Use of Mucuna Pruriens (M. Pruriens) in People with Parkinson’s Disease (PwPD)
Objective: To characterize M. pruriens use among local (primarily Argentinian) PwPD. Background: M. pruriens is a leguminous plant used in Ayurvedic medicine to treat Parkinsonism…Evaluation of Swallowing and Cough Function in older Patients with Parkinson’s Disease
Objective: This study aimed to characterize swallowing and cough function in older patients with Parkinson’s disease (PD) using a multidimensional assessment. Background: With population aging,…Neuropsychiatric Symptoms in Lewy Body Disease: Monoaminergic Activity and Resting State Networks
Objective: Investigating how neuropsychiatric symptoms (NPS)—depression, anxiety, and apathy—relate to functional connectivity between monoaminergic nuclei and the limbic network (LN), default mode network (DMN), and…Huntington’s Disease Genetic Testing Practices in the Lower North Island of New Zealand
Objective: This audit reviewed Huntington’s Disease (HD) diagnostic and predictive testing in New Zealand’s lower North Island. Key objectives included evaluating the frequency of pre-test…Predictors of Secondary Non-Response to Botulinum Neurotoxin Type-A in Cervical Dystonia: A Multi-Center Egyptian Study
Objective: To investigate clinical and treatment predictors of SNR in Egyptian CD patients receiving BoNT-A therapy. Background: Secondary non-response (SNR) to botulinum neurotoxin type-A (BoNT-A)…
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