Exploring mitochondrial mechanisms defining Parkinson’s disease penetrance in LRRK2 G2019S neuronal cultures
Objective: We explored mitochondria as integrators of genetics and environment in LRRK2 G2019S neuronal models. Specifically, we aimed to unravel mitochondrial mechanisms that define the…Understanding patient perceptions of advanced Parkinson’s disease (aPD) treatments
Objective: To explore patients’ perceptions of treatment options for aPD and treatment decision considerations. Background: As PD advances, some people with Parkinson’s (PwP) on oral…Early-onset cortico-basal degeneration (CBD) due to a c.2092G>A MAPT mutation
Objective: To describe a patient with early-onset atypical parkinsonism that evolved to a classic CBD without dementia, associated to a c.2092G>A MAPT mutation Background: Although…Parkinson’s disease management in the community
Objective: To explore perceptions of people with Parkinson's disease and family carers about the use and impact of health and social care services, community and…Uncovering the mechanisms of genotype by environment interaction in an idiopathic Parkinson’s disease model in Drosophila
Objective: To identify the genetic basis and the molecular mechanisms that underlie the susceptibility of developing motor defects in response to exposure to pesticides in…Electronic Development of the MDS-UPDRS and MDS-NMS: Process and User Feedback
Objective: To describe the processes for development and obtaining user feedback of the electronic versions of the MDS Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and…The East London Parkinson Disease Project – preliminary results from a diverse population
Objective: The East London Parkinson Disease (ELPD) project is a platform study to understand the manifestations and determinants of PD in a diverse population. Background:…Autoimmune Chorea. Therapy with Monoclonal Antibodies: Experimental and Clinical Approach
Objective: Autoimmune chorea (AICh) resulting from the appearance of paraneoplastic antibodies in response to development of malignant tumors of various localization. Sydenham's rheumatic chorea, described…Development of therapeutic substances for the disassembly of α-synuclein aggregates as disease-modifying treatment of synucleinopathies
Objective: Development of high-affinity ligands to α-synuclein (α-syn) for a therapeutic approach aiming for the disassembly of α-syn aggregates as a disease-modifying treatment of synucleinopathies.…Motor evaluation of Parkinson disease and Vascular parkinsonism using the TUG encephalog application
Objective: We aimed to compare gait and parkinsonian features between PD patients, VP patients and PD patients with Vascular component (PDVC) using a smartphone-based motion…
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